ReviewFrontiers in oncology2022
Anticancer properties of bromelain: State-of-the-art and recent trends.
Abstract readReview
In one paragraph
Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms.Nutrients · 2024Pooled it
- In Vitro Effects of an Olive Polyphenol-Bromelain Formulation on U87MG Glioblastoma Cells: Viability, Cell-Cycle Distribution, Cytokine Release, and Total Antioxidant Capacity.Molecules (Basel, Switzerland) · 2026Article
- α-Synuclein-Targeted Immunotherapies in Parkinson's Disease: In Silico, In Vitro and Clinical Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Investigation of the effects of a Kiperin Bromelain & Papain complex in normal colon, mammary, and skin cells.Scientific reports · 2026Article
- Assessment of the cytotoxic, proapoptotic, and genotoxic effects of bromelain on human peripheral blood mononuclear cells.Scientific reports · 2026Article
- A Multidisciplinary Analytical Strategy for the Authentication and Quality Assessment of Bromelain in Dietary Supplements.International journal of molecular sciences · 2026Article
- Potential health benefits of bromelain: a critical review of the current literature.Frontiers in nutrition · 2026Review
- Combined Treatment of Sodium Butyrate and Bromelain Enhanced Anticancer Effects in Colorectal Cancer Cell Lines: A Promising Therapeutic Approach.International journal of molecular sciences · 2025Article
- Niosomal Hydrogel Loaded With Bromelain: A Promising Solution for Reducing Skin Collagen in Scleroderma Patients.Journal of cellular and molecular medicine · 2025Article
- Bromelain-Infused Poly(vinyl alcohol)/Hydroxyethyl Cellulose Nanofibrous Scaffolds for Cancer Therapy: Fabrication, Characterization, andACS omega · 2025Article
- Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions.Medical oncology (Northwood, London, England) · 2025Review
- Therapeutic Potential ofCancers · 2025Review
- Protective Effects of Bromelain in Testicular Torsion-Detorsion: Reducing Inflammation, Oxidative Stress, and Apoptosis While Enhancing Sperm Quality.Biomolecules · 2025Article
- Probiotic Spores ofInternational journal of molecular sciences · 2025Article
- Anticancer Potential of Pineapple and its Bioactive Compound Bromelain.Current pharmaceutical design · 2025Review
- New Pipeline for Analysing Fruit Proteolytic Products Used as Digestive Health Nutraceuticals.International journal of molecular sciences · 2024Article
- Moscatilin, a potential therapeutic agent for cancer treatment: insights into molecular mechanisms and clinical prospects.Medical oncology (Northwood, London, England) · 2024Review
- Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies.Nutrients · 2024Review
- Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients.Journal of clinical medicine · 2024Article
- The Systematic Assessment of the Membrane-Stabilizing and Antioxidant Activities of Several Kazakhstani Plants in the Asteraceae Family.Plants (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Raffaele PezzaniPhytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy.
Manuel Jiménez-GarciaLaboratory of Neurophysiology, Biology Department, University of Balearic Islands (UIB), Palma de Mallorca, Spain.
Xavier CapóResearch Group in Community Nutrition and Oxidative Stress and Health Research Institute of the Balearic Islands (IdISBa), University of Balearic Islands, Palma de Mallorca, Spain.
Eda Sönmez GürerFaculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey.
Farukh SharopovResearch Institution "Chinese-Tajik Innovation Center for Natural Products" of the National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan.
Tchokouaha Yamthe Lauve RachelInstitute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon.
David Ntieche WoutouobaAntimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde, Yaounde, Cameroon.
Antonio RescignoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Stefania PeddioDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Paolo ZuccaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Patrick Valere Tsouh FokouDepartment of Biochemistry, Faculty of Science, University of Bamenda, Bambili, Cameroon.
Miquel MartorellDepartment of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
Zehra Gulsunoglu-KonuskanFaculty of Health Science, Nutrition and Dietetics Department, Istanbul Aydin University, Istanbul, Turkey.
Alibek YdyrysBiomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Tynybekov BekzatDepartment of Biodiversity and Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Tussupbekova GulmiraDepartment of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Christophe HanoDepartment of Biological Chemistry, University of Orleans, Chartres, France.
Javad Sharifi-RadFacultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bromelain is a key enzyme found in pineapple (
Indexed as
apoptosisbromelaincancerchemotherapeuticscytotoxicitymolecular targets
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.