Evidence map›Paper›PMID 36698194›Full record

ArticleBMC psychology2023

Determining the impact of cannabis use and severity on tobacco cessation outcomes: study protocol for a prospective tobacco treatment trial.

Kyle J Walters, Nathaniel L Baker, Rachel L Tomko, Kevin M Gray, Matthew J Carpenter, Erin A McClure

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04228965 (A Prospective Trial of Varenicline and Incentives for Tobacco Cessation in Adults), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04228965 phase4completednot on this map

A Prospective Trial of Varenicline and Incentives for Tobacco Cessation in Adults

TypeinterventionalSponsorMedical University of South CarolinaRan2020 to 2024Enrolled181ConditionsTobacco Use DisorderArmsVarenicline, Contingency Management, Counseling
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Prevalence and determinants of cigarette-cannabis co-use among US cancer survivors.Journal of cancer survivorship : research and practice · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kyle J WaltersDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St., MSC 861, Charleston, SC, 29425, USA.
Nathaniel L BakerDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA.
Rachel L TomkoDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St., MSC 861, Charleston, SC, 29425, USA.
Kevin M GrayDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St., MSC 861, Charleston, SC, 29425, USA.
Matthew J CarpenterDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St., MSC 861, Charleston, SC, 29425, USA.
Erin A McClureDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President St., MSC 861, Charleston, SC, 29425, USA. mccluree@musc.edu.
Medical University of South Carolina · USMUSC Hollings Cancer Center · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
TRAINING IN ALCOHOL TREATMENT RESEARCHT32AA007474 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J. Woodward · 1987 to 2026
$8.5M
Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trialR37CA237245 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCCLURE, ERIN A · 2019 to 2025
$4.2M
NCATS NIH HHS UL1 TR001450NCI NIH HHS R37 CA237245NIAAA NIH HHS T32 AA007474
6 · The paper itself

Abstract

backgroundSeveral evidence-based tobacco cessation treatment strategies exist, though significant barriers to cessation remain which must be addressed to improve abstinence rates for sub-populations of those smoking cigarettes. Cannabis co-use among those who use tobacco is common and appears to be increasing among adults in the United States (US). The literature evaluating the impact of cannabis use on tobacco cessation has been mixed and has several important limitations, which precludes development of treatment recommendations specific to individuals who use tobacco and co-use cannabis. To date, no prospective studies have evaluated the impact of cannabis use and severity on tobacco cessation or quantified cannabis use changes during tobacco treatment to assess for concurrent reductions, abstinence, or compensatory (i.e., increased) cannabis use. This study's aims are to: (1) evaluate tobacco cessation outcomes among participants who co-use cannabis compared to participants only using tobacco, (2) using daily diaries and biochemical verification, assess changes in cannabis use during tobacco treatment, and (3) assess for a dose-dependent impact of cannabis use on tobacco cessation.

methodA multi-site, prospective, quasi-experimental 12-week tobacco treatment trial enrolling treatment-seeking adults (ages 18-40; N = 208) from three sites across South Carolina (US) who use tobacco daily and oversampling (2:1) those who co-use cannabis. Participants receive tobacco cessation pharmacotherapy (varenicline) paired with behavioral support, while cannabis use is not addressed as part of treatment. The primary outcome is 7-day point prevalence tobacco abstinence at the week 12 end of treatment visit, measured via biochemical verification and self-report. Secondary outcome measures include changes in cannabis use (via biochemical verification and self-report) during tobacco cessation treatment. DISCUSSION: Results from this trial have the potential to inform tobacco treatment among those co-using cannabis, which may require a tailored approach to address the role of cannabis in quitting tobacco.

trial registrationThe trial is registered with ClinicalTrials.gov: NCT04228965. January 14th, 2020.

Indexed as

CannabisSmoking CessationTobacco Use CessationTobacco Use DisorderAdolescentAdultClinical Trials, Phase IV as TopicHumansMulticenter Studies as TopicNicotianaYoung AdultCannabisCo-useMarijuanaPharmacotherapyPolysubstance useTobacco cessationTreatmentVarenicline

Identifiers

PMID36698194
PMCPMC9875760
OpenAlexW4317939704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.