ArticleBMC genomics2023
Genome sequencing and comparative genomic analysis of bovine mastitis-associated Staphylococcus aureus strains from India.
Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Mastitis-Associated Bacterial Isolates and Antimicrobial Resistance in a Single Dairy Herd in the Akmola Region, Kazakhstan.Antibiotics (Basel, Switzerland) · 2026Article
- Genomic diversity and resistance determinants of staphylococci from cow and buffalo milk.Molecular biology reports · 2026Article
- Molecular epidemiological analysis of Staphylococcus aureus from hospital and food in Huai'an, Jiangsu, China, based on whole genome sequencing.Scientific reports · 2026Article
- Genomic Insights into Mammaliicoccus sciuri from Subclinical Bovine Mastitis to Unveil Key Resistance, Virulence, Biofilm and Adaptation Traits.Current microbiology · 2026Article
- Artificial intelligence based approaches for prediction of antimicrobial resistance in ruminant host pathogens.World journal of microbiology & biotechnology · 2026Article
- Genetic diversity, virulence factors and antimicrobial resistance profiles of S. aureus isolated from raw meat, meat products and veterinary samples of food-producing animals in South African provinces.BMC microbiology · 2026Article
- Single-isolate genomic characterization and cgMLST allelic comparison of a bovine mastitis-associatedFrontiers in veterinary science · 2026Article
- Systematic review on genomic insights into antimicrobial resistance in ESKAPE pathogens.African journal of laboratory medicine · 2026Review
- Study on Genomic Diversity, Prophage Distribution of Bovine-DerivedMicroorganisms · 2025Article
- Review
- Review
- Comprehensive Molecular and Epidemiological Characterization ofPathogens (Basel, Switzerland) · 2025Article
- A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness.Animals : an open access journal from MDPI · 2025Review
- The metagenomic and whole-genome metagenomic detection of multidrug-resistant bacteria from subclinical mastitis-affected cow's milk in India.Frontiers in cellular and infection microbiology · 2025Article
- Genome sequencing and comparative genomic analysis of bovine mastitis-associated non-aureus staphylococci and mammaliicocci (NASM) strains from India.Scientific reports · 2024Article
- Comprehensive whole genome analysis ofFrontiers in microbiology · 2024Article
- Deciphering the genomic character of the multidrug-resistantAIMS microbiology · 2024Article
- Genetic marker: a genome mapping tool to decode genetic diversity of livestock animals.Frontiers in genetics · 2024Review
- Three novel sequencing types from seventeenMicrobiology resource announcements · 2023Article
- Genetic and Phenotypic Characterization of Subclinical Mastitis-Causing Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBovine mastitis accounts for significant economic losses to the dairy industry worldwide. Staphylococcus aureus is the most common causative agent of bovine mastitis. Investigating the prevalence of virulence factors and antimicrobial resistance would provide insight into the molecular epidemiology of mastitis-associated S. aureus strains. The present study is focused on the whole genome sequencing and comparative genomic analysis of 41 mastitis-associated S. aureus strains isolated from India.
resultsThe results elucidate explicit knowledge of 15 diverse sequence types (STs) and five clonal complexes (CCs). The clonal complexes CC8 and CC97 were found to be the predominant genotypes comprising 21 and 10 isolates, respectively. The mean genome size was 2.7 Mbp with a 32.7% average GC content. The pan-genome of the Indian strains of mastitis-associated S. aureus is almost closed. The genome-wide SNP-based phylogenetic analysis differentiated 41 strains into six major clades. Sixteen different spa types were identified, and eight isolates were untypeable. The cgMLST analysis of all S. aureus genome sequences reported from India revealed that S. aureus strain MUF256, isolated from wound fluids of a diabetic patient, was the common ancestor. Further, we observed that all the Indian mastitis-associated S. aureus isolates belonging to the CC97 are mastitis-associated. We identified 17 different antimicrobial resistance (AMR) genes among these isolates, and all the isolates used in this study were susceptible to methicillin. We also identified 108 virulence-associated genes and discuss their associations with different genotypes.
conclusionThis is the first study presenting a comprehensive whole genome analysis of bovine mastitis-associated S. aureus isolates from India. Comparative genomic analysis revealed the genome diversity, major genotypes, antimicrobial resistome, and virulome of clinical and subclinical mastitis-associated S. aureus strains.
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