Evidence map›Paper›PMID 36698055›Full record

ArticleBMC cardiovascular disorders2023

Cost-effectiveness of an insertable cardiac monitor in a high-risk population in the US.

Mitchell S V Elkind, Klaus K Witte, Scott E Kasner, Laura M Sawyer, Frank W Grimsey Jones, Claudia Rinciog, Stelios Tsintzos, Sarah C Rosemas, David Lanctin, Paul D Ziegler and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Klaus K WitteLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Scott E KasnerDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Laura M SawyerSymmetron Limited, 8 Devonshire Square, London, EC2M 4PL, UK. lsawyer@symmetron.net.
Frank W Grimsey JonesSymmetron Limited, 8 Devonshire Square, London, EC2M 4PL, UK.
Claudia RinciogSymmetron Limited, 8 Devonshire Square, London, EC2M 4PL, UK.
Stelios TsintzosMedtronic, Mounds View, MN, USA.
Sarah C RosemasMedtronic, Mounds View, MN, USA.
David LanctinMedtronic, Mounds View, MN, USA.
Paul D ZieglerMedtronic, Mounds View, MN, USA.
Matthew R ReynoldsBaim Institute for Clinical Research, Boston, MA, USA.
Medtronic (United States) · USColumbia University · USLahey Medical Center · USMedtronic (Ireland) · IERWTH Aachen University · DEUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsertable cardiac monitors (ICMs) are a clinically effective means of detecting atrial fibrillation (AF) in high-risk patients, and guiding the initiation of non-vitamin K oral anticoagulants (NOACs). Their cost-effectiveness from a US clinical payer perspective is not yet known. The objective of this study was to evaluate the cost-effectiveness of ICMs compared to standard of care (SoC) for detecting AF in patients at high risk of stroke (CHADS

methodsUsing patient data from the REVEAL AF trial (n = 393, average CHADS

resultsLifetime per-patient cost for ICM was $31,116 versus $25,330 for SoC. ICMs generated a total of 7.75 QALYs versus 7.59 for SoC, with 34 fewer strokes projected per 1000 patients. The model estimates a number needed to treat of 29 per stroke avoided. The incremental cost-effectiveness ratio was $35,528 per QALY gained. ICMs were cost-effective in 75% of PSA simulations, using a $50,000 per QALY threshold, and a 100% probability of being cost-effective at a WTP threshold of $150,000 per QALY.

conclusionsThe use of ICMs to identify AF in a high-risk population is likely to be cost-effective in the US healthcare setting.

Indexed as

Atrial FibrillationAdministration, OralAnticoagulantsClinical Trials as TopicCost-Benefit AnalysisHemorrhageHumansQuality-Adjusted Life YearsStrokeAnticoagulantsAtrial fibrillationCardiologyDiagnosticsEconomic evaluationStroke

Identifiers

PMID36698055
PMCPMC9875401
OpenAlexW4317889066

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.