ArticleCommunications chemistry2022
Proton transfer during DNA strand separation as a source of mutagenic guanine-cytosine tautomers.
Article in Communications chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Redirecting Excited-State Proton Transfer Through Supramolecular Polymerization in Nanoconfinement.Angewandte Chemie (International ed. in English) · 2026Article
- Quantum biology: From mechanisms to medicine.Clinical and translational medicine · 2026Review
- The Rigid Double Harmonic Oscillator Model of DNA Base Pairs and the Wignerian Approach for the Transition Rate of Single-Proton Transfer within the Fermi Golden Rule.The journal of physical chemistry. B · 2026Article
- Modelling double proton tunneling along low-barrier hydrogen bonds through time-dependent Fourier grid Hamiltonian method.Journal of molecular modeling · 2025Article
- Multiscale simulations reveal the role of PcrA helicase in protecting against spontaneous point mutations in DNA.Scientific reports · 2023Article
- Environment assisted quantum model for studying RNA-DNA-error correlation created due to the base tautomery.Scientific reports · 2023Article
- Tautomerisation Mechanisms in the Adenine-Thymine Nucleobase Pair during DNA Strand Separation.The journal of physical chemistry. B · 2023Article
- How proton transfer impacts hachimoji DNA.RSC advances · 2023Article
- Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerism.The journal of physical chemistry letters · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Proton transfer between the DNA bases can lead to mutagenic Guanine-Cytosine tautomers. Over the past several decades, a heated debate has emerged over the biological impact of tautomeric forms. Here, we determine that the energy required for generating tautomers radically changes during the separation of double-stranded DNA. Density Functional Theory calculations indicate that the double proton transfer in Guanine-Cytosine follows a sequential, step-like mechanism where the reaction barrier increases quasi-linearly with strand separation. These results point to increased stability of the tautomer when the DNA strands unzip as they enter the helicase, effectively trapping the tautomer population. In addition, molecular dynamics simulations indicate that the relevant strand separation time is two orders of magnitude quicker than previously thought. Our results demonstrate that the unwinding of DNA by the helicase could simultaneously slow the formation but significantly enhance the stability of tautomeric base pairs and provide a feasible pathway for spontaneous DNA mutations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.