Evidence map›Paper›PMID 36697871›Full record

ReviewNature protocols2023

Whole-mouse clearing and imaging at the cellular level with vDISCO.

Ruiyao Cai, Zeynep Ilgin Kolabas, Chenchen Pan, Hongcheng Mai, Shan Zhao, Doris Kaltenecker, Fabian F Voigt, Muge Molbay, Tzu-Lun Ohn, Cécile Vincke and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
26.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Review
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  4. Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Ruiyao Cai *Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Zeynep Ilgin Kolabas *Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Chenchen PanInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Hongcheng MaiInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.ORCID 0000-0001-6615-0157
Shan ZhaoInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Doris KalteneckerInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Fabian F VoigtBrain Research Institute, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7108-2176
Muge MolbayInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Tzu-Lun OhnInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Cécile VinckeLaboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Mihail I TodorovInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany.
Fritjof HelmchenBrain Research Institute, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-8867-9569
Jo A Van GinderachterLaboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Ali ErtürkInstitute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Munich, Germany. erturk@helmholtz-muenchen.de.ORCID 0000-0001-5163-5100
Helmholtz Zentrum München · DEUniversity of Zurich · CHVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homeostatic and pathological phenomena often affect multiple organs across the whole organism. Tissue clearing methods, together with recent advances in microscopy, have made holistic examinations of biological samples feasible. Here, we report the detailed protocol for nanobody(V

Indexed as

BrainImaging, Three-DimensionalAnimalsColoring AgentsMiceMicroscopy, FluorescenceNeuritesSolventsColoring AgentsSolvents

Identifiers

PMID36697871
OpenAlexW4317952698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.