ArticleNature2023
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
23.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
109 citing papers in PubMed, 158 citations in OpenAlex.
- Amino acid composition of plant protein-enriched wheat biscuits differentially affects postprandial amino acid responses of overweight/obese compared to normalweight subjects.European journal of nutrition · 2025Trial
- SPTLC2-driven sphingolipid reprogramming of neutrophils impairs anti-tumour immunity and drives liver cancer progression.Oncogene · 2026Article
- ROS/pH-Responsive Phenylboronic Acid-Chitosan Nanoparticles Improve Silymarin-Mediated Hepatoprotection After Hepatectomy With Gut-Liver Axis-Associated Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Amino Acid Metabolism in Health and Disease.MedComm · 2026Review
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation.Physiological reports · 2026Review
- Convergent human genetic evidence implicates serine biosynthesis in diabetic peripheral neuropathy.medRxiv : the preprint server for health sciences · 2026Article
- L-Serine Attenuates Metabolic and Behavioural Features of Diabetic Neuropathy with Dose-Dependent Central Proteomic Correlates in a Rat Model.Biomolecules · 2026Article
- Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.Nature communications · 2026Article
- Microbiota transplantation and multi-omics profiling integration unveil the mechanism of Alistipes communis-driven abdominal fat deposition in chickens.Journal of animal science and biotechnology · 2026Article
- NR4A3 alleviates diabetic neuropathy via GLS2-mediated mitochondrial repair and Schwann cell differentiation.iScience · 2026Article
- Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment.bioRxiv : the preprint server for biology · 2026Article
- Serine Supplementation Attenuates High-Selenium-Induced Insulin Resistance via Feedback Inhibition of PHGDH in Mice.Biological trace element research · 2026Article
- Host insulin hijacking by a nematode receptor mediates developmental plasticity and sex ratio shifts.Nature communications · 2026Article
- Higher plasma serine levels are associated with favorable values of metabolic health markers among middle-aged and older adults in The Maastricht Study.GeroScience · 2026Article
- O-Acetyl-Serine Supplementation Enhances Insulin Secretion and Improves Postprandial Glycaemia in Lean and Prediabetic Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Serine inhibits granulosa cell ferroptosis to maintain ovarian function.Nature communications · 2026Article
- Comparative profiling of amino acids in plasma and serum across children and adults using LC-MS/MS and its implications for precision nutrition.Frontiers in nutrition · 2026Article
- Neurological manifestations in metabolic dysfunction syndrome are associated with cumulative metabolic burden beyond hyperglycaemia: a translational study.Frontiers in endocrinology · 2026Article
- The Central Role of Lipid Metabolism Disorders in Diabetes Mellitus: Mechanisms, Clinical Manifestations, and Emerging Therapeutic Strategies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Michal K HandzlikMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4653-1902
Jivani M GengatharanMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Katie E FrizziDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Grace H McGregorMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Cameron MartinoDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9334-1258
Gibraan RahmanDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Antonio GonzalezDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Ana M MorenoDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Courtney R GreenMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Lucie S GuernseyDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Terry LinRegulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1766-6066
Patrick TsengMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6536-5647
Yoichiro IdeguchiScripps Research, La Jolla, CA, USA.
Regis J FallonLowy Medical Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-2391-2534
Amandine ChaixDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-7007-197X
Satchidananda PandaRegulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Prashant MaliDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3383-1287
Martina WallaceSchool of Agriculture and Food Science, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0001-8272-5678
Rob KnightDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Marin L GantnerLowy Medical Research Institute, La Jolla, CA, USA.
Nigel A CalcuttDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Christian M MetalloMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. metallo@salk.edu.ORCID http://orcid.org/0000-0003-2404-3040
University of California San Diego · USSalk Institute for Biological Studies · USThe Lowy Medical Research Institute · USScripps Institution of Oceanography · USUniversity College Dublin · IEUniversity of Utah · US
Funding
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8MPathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9MMechanisms by which time-restricted feeding (TRF) delays the onset of age-related declines in health, cognition, and circadian rhythmsR01AG065993 · NIA · UNIVERSITY OF UTAH · PI CHAIX, AMANDINE H. · 2019 to 2023
$2.1MNon-essential amino acids and sphingolipid diversity in cancer progressionR01CA234245 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI METALLO, CHRISTIAN MICHAEL · 2019 to 2023
$1.9MNCI NIH HHS R01 CA234245NIA NIH HHS R01 AG065993NIDDK NIH HHS P30 DK120515NIDDK NIH HHS U24 DK076169NIGMS NIH HHS T32 GM133351
Abstract
Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves
Indexed as
Diabetes Mellitus, ExperimentalInsulinLipid MetabolismPeripheral Nervous System DiseasesSerineAdiposityAnimalsDiet, High-FatDyslipidemiasFatty Acids, MonounsaturatedGlycineMiceSmall Fiber NeuropathySphingolipidsFatty Acids, MonounsaturatedGlycineInsulinSerineSphingolipidsthermozymocidin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.