Evidence map›Paper›PMID 36697694›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2023

Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder.

Carl Bose, Gregory C Valentine, Kamaira Philips, Kim Boggess, Kevin Moss, Silvana P Barros, Julie Marchesan, Di Wu, Thomas M O'Shea, Myriam Peralta-Carcelen and 3 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03423836 (Maternal Oral Therapy to Reduce Obstetric Risk Kids), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03423836 completednot on this map

Maternal Oral Therapy to Reduce Obstetric Risk Kids

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2007 to 2013Enrolled331ConditionsPeriodontitis, Autism, Premature Infants
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Carl Bose *Division of Neonatal and Perinatal Medicine, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Gregory C Valentine *Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, USA. gcvalent@uw.edu.ORCID 0000-0002-3055-2987
Kamaira PhilipsDivision of Oral Health and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Kim BoggessDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Kevin MossDivision of Oral Health and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Silvana P BarrosDivision of Comprehensive Oral Health, Periodontology Unit, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Julie MarchesanDivision of Comprehensive Oral Health, Periodontology Unit, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Di WuDivision of Oral Health and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Thomas M O'SheaDivision of Neonatal and Perinatal Medicine, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Myriam Peralta-CarcelenDepartment of Pediatrics, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Ricki GoldsteinDivision of Neonatology, Department of Pediatrics, Kentucky Children's Hospital, Lexington, KY, USA.
Rajam RamamurthyDivision of Neonatology, Department of Pediatrics, University of Texas Health Science Center, San Antonio, TX, USA.
James D BeckDivision of Comprehensive Oral Health, Periodontology Unit, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USShriners Hospitals for Children Medical Center - Lexington · USThe University of Texas Health Science Center at San Antonio · USUniversity of Alabama at Birmingham · USUniversity of Washington · US

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
MOTOR-Maternal Oral Therapy to Reduce Obstetric RiskU01DE014577 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OFFENBACHER, STEVEN · 2003 to 2010
$12.6M
IFI16 is a Periodontitis Modulating ProteinK01DE027087 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARCHESAN, JULIE TERESA · 2017 to 2022
$833k
Prevention of Developmental Delay and Xylitol (PDDaX) StudyK23HD105929 · NICHD · UNIVERSITY OF WASHINGTON · PI Gregory Charles Valentine · 2022 to 2026
$798k
NCRR NIH HHS UL1 RR025747NICHD NIH HHS K23 HD105929NIDCR NIH HHS K01 DE027087NIDCR NIH HHS U01 DE014577
6 · The paper itself

Abstract

backgroundTo evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD).

methodsIn a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6).

resultsToddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29-0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03).

conclusionsTreating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. CLINICAL TRIAL: Trial Registration numbers: Clinicaltrials.gov NCT03423836.

Indexed as

Autism Spectrum DisorderPeriodontal DiseasesPeriodontitisChecklistFollow-Up StudiesHumansInfantInterleukin-6Mass ScreeningInterleukin-6

Identifiers

PMID36697694
OpenAlexW4317931231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.