Evidence map›Paper›PMID 36697642›Full record

ArticleCommunications chemistry2022

Detection of the UV-vis silent biomarker trimethylamine-N-oxide via outer-sphere interactions in a lanthanide metal-organic framework.

Hui Min, Zhonghang Chen, Zongsu Han, Kunyu Wang, Jun Xu, Wei Shi, Peng Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Biomaterials for biomarker imaging and detection.Journal of advanced research · 2026
    Review
  3. Metal-Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hui MinDepartment of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.
Zhonghang ChenDepartment of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.
Zongsu HanDepartment of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.
Kunyu WangDepartment of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.
Jun XuSchool of Materials Science and Engineering & National Institute for Advanced Materials Center for Rare Earth and Inorganic Functional Materials, Tianjin Key Lab for Rare Earth Materials and Applications, Nankai University, Tianjin, 300350, China.
Wei ShiDepartment of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China. shiwei@nankai.edu.cn.ORCID http://orcid.org/0000-0001-6130-1227
Peng ChengDepartment of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.
Nankai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trimethylamine-N-oxide (TMAO) is a biomarker of the cardiovascular disease that is one of the leading causes of worldwide death. Facile detection of TMAO can significantly improve the survival rate of this disease by allowing early prevention. However, the UV-vis silent nature of TMAO makes it intricated to be detected by conventional sensing materials or analytical instruments. Here we show a bilanthanide metal-organic framework functionalized by borono group for the recognition of TMAO. Superior sensitivity, selectivity and anti-interference ability were achieved by the inverse emission intensity changes of the two lanthanide centers. The limit of detection is 15.6 μM, covering the clinical urinary concentration range of TMAO. A smartphone application was developed based on the change in R-G-B chromaticity. The sensing mechanism via a well-matched outer-sphere interaction governing the sensing function was studied in detail, providing fundamentals in molecular level for the design of advanced sensing materials for UV-Vis silent molecules.

Identifiers

PMID36697642
PMCPMC9814541
OpenAlexW4283278393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.