ArticleCommunications chemistry2021
A cascade double 1,4-addition/intramolecular annulation strategy for expeditious assembly of unsymmetrical dibenzofurans.
Article in Communications chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Divergent Three-Component Assembly of Densely Functionalized Dibenzofurans via ZnClOrganic letters · 2026Article
- Ortho-Alkynyl Quinone Methides as Privileged Intermediates in Synthesis of Polycyclic Frameworks: A Short Review.Chemical record (New York, N.Y.) · 2026Review
- A Palladium-Catalyzed Cascade Double Annulation Strategy for Modular Access to Dihydrocyclopenta[Organic letters · 2025Article
- Cascade Annulation Strategy for Expeditious Assembly of Hydroxybenzo[The Journal of organic chemistry · 2023Article
- An expeditious FeClChemical science · 2022Article
- Radical-Induced Cascade Annulation/Hydrocarbonylation for Construction of 2-Aryl-4Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Existing synthetic routes for accessing dibenzofuran core have intrinsic regioselectivity, limiting the substitution patterns available in heteropolycyclic arene products. Here we report a double 1,4-conjugate addition/intramolecular annulation cascade reaction between propargylamines and two equivalents of imidazolium methylides that allows efficient access of structurally versatile dibenzofurans. This transition metal-free protocol proceeds smoothly under bench-top air atmosphere and offers easy manipulation of substituents on the dibenzofuran core, and also provides good-to-excellent product yields with good functional group tolerance, particularly the -Br and -Cl groups which are often incompatible with existing metal-catalyzed C-C and/or C-O bond ring-forming processes. It is worth noting that ladder-type π-systems with all-arene quarternary carbon structure can be straightforwardly generated upon simple late-stage functionalization.
Identifiers
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Registered trials
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