Evidence map›Paper›PMID 36697587›Full record

ArticleCommunications chemistry2022

Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2.

Genwei Zhang, Joseph S Brown, Anthony J Quartararo, Chengxi Li, Xuyu Tan, Stephanie Hanna, Sarah Antilla, Amanda E Cowfer, Andrei Loas, Bradley L Pentelute

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Cell-free Biosynthesis of Peptidomimetics.Biotechnology and bioprocess engineering : BBE · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Genwei Zhang *Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0002-5737-8413
Joseph S Brown *Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0002-8145-800X
Anthony J QuartararoMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-4995-1424
Chengxi LiMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-3904-0299
Xuyu TanMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Stephanie HannaMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Sarah AntillaMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0002-3592-0857
Amanda E CowferMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Andrei LoasMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Bradley L PenteluteMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA. blp@mit.edu.ORCID http://orcid.org/0000-0002-7242-801X
Massachusetts Institute of Technology · USBroad Institute · USFoghorn Therapeutics (United States) · US

Funding

National Science Foundation (NSF) 1122374
6 · The paper itself

Abstract

Rapid discovery and development of serum-stable, selective, and high affinity peptide-based binders to protein targets are challenging. Angiotensin converting enzyme 2 (ACE2) has recently been identified as a cardiovascular disease biomarker and the primary receptor utilized by the severe acute respiratory syndrome coronavirus 2. In this study, we report the discovery of high affinity peptidomimetic binders to ACE2 via affinity selection-mass spectrometry (AS-MS). Multiple high affinity ACE2-binding peptides (ABP) were identified by selection from canonical and noncanonical peptidomimetic libraries containing 200 million members (dissociation constant, K

Identifiers

PMID36697587
PMCPMC9814530
OpenAlexW4206597352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.