Evidence map›Paper›PMID 36697312›Full record

ArticleVaccine2023

Comparative performance of between-population vaccine allocation strategies with applications for emerging pandemics.

Keya Joshi, Eva Rumpler, Lee Kennedy-Shaffer, Rafia Bosan, Marc Lipsitch

Abstract read
In one paragraph

Article in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Keya JoshiCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, 02115 Boston, MA, USA.
Eva RumplerCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, 02115 Boston, MA, USA.
Lee Kennedy-ShafferCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, 02115 Boston, MA, USA; Department of Mathematics & Statistics, Vassar College, 12604 Poughkeepsie, NY, USA.
Rafia BosanCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, 02115 Boston, MA, USA.
Marc LipsitchCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, 02115 Boston, MA, USA.

Funding

Epidemiology of Infectious Diseases and BiodefenseT32AI007535 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GRAD, YONATAN H, MURRAY, MEGAN B · 1998 to 2025
$4.8M
Casual, Statistical and Mathematical Modeling with Serologic DataU01CA261277 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM, LIPSITCH, MARC · 2020 to 2023
$2.8M
NCI NIH HHS U01 CA261277NIAID NIH HHS T32 AI007535
6 · The paper itself

Abstract

Vaccine allocation decisions during emerging pandemics have proven to be challenging due to competing ethical, practical, and political considerations. Complicating decision making, policy makers need to consider vaccine allocation strategies that balance needs both within and between populations. When vaccine stockpiles are limited, doses should be allocated in locations to maximize their impact. Using a susceptible-exposed-infectious-recovered (SEIR) model we examine optimal vaccine allocation decisions across two populations considering the impact of characteristics of the population (e.g., size, underlying immunity, heterogeneous risk structure, interaction), vaccine (e.g., vaccine efficacy), pathogen (e.g., transmissibility), and delivery (e.g., varying speed and timing of rollout). Across a wide range of characteristics considered, we find that vaccine allocation proportional to population size (i.e., pro-rata allocation) performs either better or comparably to nonproportional allocation strategies in minimizing the cumulative number of infections. These results may argue in favor of sharing of vaccines between locations in the context of an epidemic caused by an emerging pathogen, where many epidemiologic characteristics may not be known.

Indexed as

PandemicsVaccinesAdministrative PersonnelDisease SusceptibilityHumansPopulation DensityVaccinesEmerging pathogenPandemicsVaccine allocationVaccine distribution

Identifiers

PMID36697312
PMCPMC10075509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.