ArticleNeurology2023
Premature Cardiovascular Disease and Brain Health in Midlife: The CARDIA Study.
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Premature coronary artery disease in women: sex-specific risk factors, pathogenetic mechanisms and clinical implications.Annals of medicine · 2026Review
- Epigenetic Clock Trajectories and Brain Health in Midlife.medRxiv : the preprint server for health sciences · 2026Article
- Cross-organ MRI to assess the relationship between cardiac traits and cerebral white matter hyperintensity volumes.Communications medicine · 2026Article
- Mitochondrial haplogroups, but not heteroplasmy, are associated with midlife cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Long-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults.Neurology · 2025Article
- Associations of early-onset coronary heart disease and genetic susceptibility with incident dementia and white matter hyperintensity: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults.Frontiers in aging neuroscience · 2025Article
- Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging.Frontiers in physiology · 2025Review
- Concussion burden and later-life cardiovascular risk factors in former professional American-style football players.Annals of clinical and translational neurology · 2024Article
- Cardiovascular disease and preventive care service utilization among midlife adults: The roles of diagnosis and depression.American journal of preventive cardiology · 2024Article
- Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age.BMC geriatrics · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Iron load in the normal aging brain measured with QSM andFrontiers in neuroimaging · 2024Article
- Risk factors for cognitive dysfunction amongst patients with cardiovascular diseases.Frontiers in public health · 2024Article
- Age at Diagnosis of Atrial Fibrillation and Incident Dementia.JAMA network open · 2023Article
- Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health.Expert review of neurotherapeuticsReview
- Cardiometabolic disease, cognitive decline, and brain structure in middle and older age.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesTo understand the role of premature (defined as ≤ 60 years) cardiovascular disease (CVD) in brain health earlier in life, we examined the associations of premature CVD with midlife cognition and white matter health.
methodsWe studied a prospective cohort in the Coronary Artery Risk Development in Young Adults study, who were 18-30 years at baseline (1985-1986) and followed up to 30 years when 5 cognitive tests measuring different domains were administered. A subset (656 participants) had brain MRI measures of white matter hyperintensity (WMH) and white matter integrity. A premature CVD event was adjudicated based on medical records of coronary heart disease, stroke/TIA, congestive heart failure, carotid artery disease, and peripheral artery disease. We conducted linear regression to determine the associations of nonfatal premature CVD with cognitive performance (z-standardized), cognitive decline, and MRI measures.
resultsAmong 3,146 participants, the mean age (57% women and 48% Black) was 55.1 ± 3.6 years, with 5% (n = 147) having premature CVD. Adjusting for demographics, education, literacy, income, depressive symptoms, physical activity, diet, and DISCUSSION: Premature CVD is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVRFs. Preventing CVD in early adulthood may delay the onset of cognitive decline and promote brain health over the life course.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.