Evidence map›Paper›PMID 36697156›Full record

Trial reportJACC. Cardiovascular interventions2023

Transient vs In-Hospital Persistent Acute Kidney Injury in Patients With Acute Coronary Syndrome.

Antonio Landi, Mattia Branca, Sergio Leonardi, Enrico Frigoli, Pascal Vranckx, Matteo Tebaldi, Ferdinando Varbella, Paolo Calabró, Giovanni Esposito, Gennaro Sardella and 14 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in JACC. Cardiovascular interventions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01433627 (Phase IIIb Study Minimizing Adverse Haemmhorragic Events by TRansradial Access Site and Systemic Implementation of angioX), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01433627 phase3unknown statusnot on this map

Phase IIIb Study Minimizing Adverse Haemmhorragic Events by TRansradial Access Site and Systemic Implementation of angioX (MATRIX)

TypeinterventionalSponsorItalian Society of Invasive CardiologyRan2011 to 2015Enrolled7,200ConditionsAcute Coronary Syndromes, STEMI, NSTEMIArmstrans-radial and short-term bivalirudin, trans-radial and long-term bivalirudin infusion, trans-radial and standard of care pharmacology, Trans-femoral and Short-term bivalirudin, trans-femoral and long-term bivalirudin infusion
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 18 institutions in 5 countries.

Antonio LandiDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Mattia BrancaCTU Bern, University of Bern, Switzerland.
Sergio LeonardiUniversity of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Enrico FrigoliDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland; CTU Bern, University of Bern, Switzerland.
Pascal VranckxDepartment of Cardiology and Critical Care Medicine, Hartcentrum Hasselt, Jessa Ziekenhuis, Hasselt, Belgium; Faculty of Medicine and Life Sciences, University of Hasselt, Hasselt, Belgium.
Matteo TebaldiCardiology Unit, Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy.
Ferdinando VarbellaCardiology Unit, Ospedali Riuniti di Rivoli, ASL Torino 3, Turin, Italy; Cardiology Unit, Azienda Ospedaliera Universitaria San Luigi Gonzaga Orbassano, Turin, Italy.
Paolo CalabróDivision of Cardiology, "Sant'Anna e San Sebastiano" Hospital, Caserta, Italy; Department of Translational Medicine, University of Campania "Luigi Vanvitelli," Caserta, Italy.
Giovanni EspositoDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.
Gennaro SardellaDepartment of Cardiovascular Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Stefano GarducciVimercate Hospital, ASST della Brianza, Italy.
Giuseppe AndòAzienda Ospedaliera Universitaria Policlinico "Gaetano Martino," University of Messina, Messina, Italy.
Ugo LimbrunoCardiology Department, Misericordia Hospital, Grosseto, Italy.
Paolo SganzerlaIRCCS Istituto Auxologico Italiano, Ospedale San Luca, Milano.
Andrea SantarelliCardiology Unit, Infermi Hospital, Rimini, Italy.
Carlo BriguoriInterventional Cardiology Unit, Mediterranea Cardiocentro, Naples, Italy.
Salvatore ColangeloCardiovascular Intervention Unit, San Giovanni Bosco Hospital, Turin, Italy.
Salvatore BrugalettaHospital Clínic, Cardiovascular Clinic Institute, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Marianna AdamoCardiac Catheterization Laboratory and Cardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Elmir OmerovicDepartment of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Dik HegCTU Bern, University of Bern, Switzerland.
Stephan WindeckerDepartment of Cardiology, Inselspital, University of Bern, Bern, Switzerland.
Marco ValgimigliDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland; Department of Biomedical Sciences, University of Italian Switzerland, Lugano, Switzerland. Electronic address: marco.valgimigli@eoc.ch.
MATRIX Investigators
University of Bern · CHEnte Ospedaliero Cantonale · CHAzienda Ospedaliera di Desio e Vimercate · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITClinica Mediterranea · ITHospital Clínic de Barcelona · ESIRCCS Istituto Auxologico Italiano · ITJessa Hospital · BEOspedale di Rivoli · ITOspedale Infermi di Rimini · ITOspedale Misericordia - Grosseto · ITOspedale San Giovanni Bosco · ITPoliclinico Umberto I · ITSahlgrenska University Hospital · SEUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Messina · ITUniversity of Naples Federico II · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe occurrence of acute kidney injury (AKI) among patients with acute coronary syndrome (ACS) undergoing invasive management is associated with worse outcomes. However, the prognostic implications of transient or in-hospital persistent AKI may differ.

objectivesThe aim of this study was to evaluate the prognostic implications of transient or in-hospital persistent AKI in patients with ACS.

methodsIn the MATRIX (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial, 203 subjects were excluded because of incomplete information or end-stage renal disease, with a study population of 8,201 patients. Transient and persistent AKI were defined as renal dysfunction no longer or still fulfilling the AKI criteria (>0.5 mg/dL or a relative >25% increase in creatinine) at discharge, respectively. Thirty-day coprimary outcomes were the out-of-hospital composite of death, myocardial infarction, or stroke (major adverse cardiovascular events [MACE]) and net adverse cardiovascular events (NACE), defined as the composite of MACE or Bleeding Academic Research Consortium type 3 or 5 bleeding.

resultsPersistent and transient AKI occurred in 750 (9.1%) and 587 (7.2%) subjects, respectively. After multivariable adjustment, compared with patients without AKI, the risk for 30-day coprimary outcomes was higher in patients with persistent AKI (MACE: adjusted HR: 2.32; 95% CI: 1.48-3.64; P < 0.001; NACE: adjusted HR: 2.29; 95% CI: 1.48-3.52; P < 0.001), driven mainly by all-cause mortality (adjusted HR: 3.43; 95% CI: 2.03-5.82; P < 0.001), whereas transient AKI was not associated with higher rates of MACE or NACE. Results remained consistent when implementing the KDIGO (Kidney Disease Improving Global Outcomes) criteria.

conclusionsAmong patients with ACS undergoing invasive management, in-hospital persistent but not transient AKI was associated with higher risk for 30-day MACE and NACE. (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox [MATRIX]; NCT01433627).

Indexed as

Acute Coronary SyndromeAcute Kidney InjuryMyocardial InfarctionPercutaneous Coronary InterventionHemorrhageHumansRisk FactorsTreatment Outcomeacute coronary syndromepercutaneous coronary interventionpersistent acute kidney injurytransient acute kidney injury

Identifiers

PMID36697156
OpenAlexW4313419954

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.