Evidence map›Paper›PMID 36697134›Full record

Observational studyJournal of the American College of Cardiology2023

Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.

Andrej Ćorović, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert and 33 more

Registry-linked trialOpen access · hybridAbstract readObservational Study
In one paragraph

Observational study in Journal of the American College of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06226987 (Molecular Imaging in Fabry Disease of the Heart), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06226987 unknown statusnot on this mapstarted 2024, after this paper: background citation

Molecular Imaging in Fabry Disease of the Heart

TypeobservationalSponsorUniversity of CambridgeRan2024 to 2026Enrolled12ConditionsFabry Disease, Cardiac VariantArms68Ga-DOTATATE PET/MRI
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Guideline
  2. Cardiovascular imaging with total-body PET.The British journal of radiology · 2026
    Review
  3. Coronary artery disease imaging with total-body PET.The British journal of radiology · 2026
    Review
  4. Article
  5. Review
  6. Management of Takayasu Arteritis - A 2026 Update.Current rheumatology reports · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Emerging PET radiotracers for vascular imaging.Rheumatology (Oxford, England) · 2025
    Review
  18. Comparison of [EJNMMI reports · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors at 14 institutions in 3 countries.

Andrej ĆorovićSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Christopher WallSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Meritxell NusSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Deepa GopalanDepartment of Radiology, Imperial College Healthcare National Health Service (NHS) Trust, London, United Kingdom; Department of Radiology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.
Yuan HuangEngineering and Physical Sciences Research Council Centre for Mathematical Imaging in Healthcare, University of Cambridge, Cambridge, United Kingdom.
Maria ImazSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Michal ZulcinskiLeeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Marta PeverelliSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom; Vascular Sciences, National Heart & Lung Institute, Imperial College London, London, United Kingdom.
Anna UrygaSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Jordi LambertSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Dario BressanCancer Research UK Cambridge Institute, Cambridge, United Kingdom.
Robert T MaughanVascular Sciences, National Heart & Lung Institute, Imperial College London, London, United Kingdom.
Charis PericleousVascular Sciences, National Heart & Lung Institute, Imperial College London, London, United Kingdom.
Suraiya DubashDepartment of Oncology, University College London NHS Trust, London, United Kingdom; Department of Surgery & Cancer, Imperial College London, London, United Kingdom.
Natasha JordanDepartment of Rheumatology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.
David R JayneDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Stephen P HooleDepartment of Cardiology, Royal Papworth Hospital NHS Trust, Cambridge, United Kingdom.
Patrick A CalvertDepartment of Cardiology, Royal Papworth Hospital NHS Trust, Cambridge, United Kingdom.
Andrew F DeanDepartment of Histopathology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.
Doris RasslDepartment of Histopathology, Royal Papworth Hospital NHS Trust, Cambridge, United Kingdom.
Tara BarwickDepartment of Radiology, Imperial College Healthcare National Health Service (NHS) Trust, London, United Kingdom; Department of Surgery & Cancer, Imperial College London, London, United Kingdom.
Mark IlesLeeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Mattia FrontiniInstitute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.
Greg HannonCancer Research UK Cambridge Institute, Cambridge, United Kingdom.
Roido ManavakiDepartment of Radiology, University of Cambridge, Cambridge, United Kingdom.
Tim D FryerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Luigi AlojDepartment of Radiology, University of Cambridge, Cambridge, United Kingdom.
Martin J GravesDepartment of Radiology, University of Cambridge, Cambridge, United Kingdom.
Fiona J GilbertDepartment of Radiology, University of Cambridge, Cambridge, United Kingdom.
Marc R DweckCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
David E NewbyCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Zahi A FayadBioMedical Engineering & Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gary ReynoldsDepartment of Rheumatology, University of Newcastle, Newcastle, United Kingdom.
Ann W MorganLeeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Eric O AboagyeDepartment of Surgery & Cancer, Imperial College London, London, United Kingdom.
Anthony P DavenportSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Helle F JørgensenSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Ziad MallatSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Martin R BennettSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
James E PetersCentre for Inflammatory Disease, Imperial College London, London, United Kingdom.
James H F RuddSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom.
Justin C MasonVascular Sciences, National Heart & Lung Institute, Imperial College London, London, United Kingdom.
Jason M TarkinSection of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom; Vascular Sciences, National Heart & Lung Institute, Imperial College London, London, United Kingdom. Electronic address: jt545@cam.ac.uk.
University of Cambridge · GBImperial College London · GBPapworth Hospital · GBUniversity of Leeds · GBCambridge University Hospitals NHS Foundation Trust · GBCancer Research UK Cambridge Center · GBNational Health Service · GBUniversity of Edinburgh · GBEngineering and Physical Sciences Research Council · GBIcahn School of Medicine at Mount Sinai · USLung Institute · USUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Exeter · GBUniversity of Newcastle Australia · AU

Funding

Ga68-DOTATATE PET imaging of plaque inflammationR01HL135878 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2017 to 2020
$2.9M
British Heart Foundation 18/1/34212British Heart Foundation CH/09/002/26360British Heart Foundation CH/10/001/27642British Heart Foundation CH/2000003/12800British Heart Foundation FS/14/78/31020British Heart Foundation FS/18/53/33863British Heart Foundation FS/20/23/34784British Heart Foundation FS/CRTF/20/24035British Heart Foundation PG/18/14/33562British Heart Foundation PG/22/10898British Heart Foundation RG/10/001/27643British Heart Foundation RG/16/10/32375British Heart Foundation RG/20/2/34763British Heart Foundation TG/18/4/33770Cancer Research UK A25177Department of HealthMedical Research Council G0701127Medical Research Council MR/J007986/1Medical Research Council MR/N011775/1Medical Research Council MR/N020782/1Medical Research Council MR/N028015/1Medical Research Council MR/S004068/2NHLBI NIH HHS R01 HL135878Versus Arthritis 21223Wellcome Trust 211100/Z/18/Z
6 · The paper itself

Abstract

backgroundAssessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures.

objectivesWe aimed to investigate somatostatin receptor 2 (SST

methodsIn a prospective, observational cohort study, in vivo arterial SST

resultsSixty-one participants (LVV: n = 27; recent atherosclerotic myocardial infarction of ≤2 weeks: n = 25; control subjects with an oncologic indication for imaging: n = 9) were included. Index vessel SST

conclusionsSST

Indexed as

AtherosclerosisGiant Cell ArteritisMyocardial InfarctionTakayasu ArteritisCoronary VesselsFluorodeoxyglucose F18HumansInflammationMagnetic Resonance ImagingPositron-Emission TomographyProspective StudiesRadiopharmaceuticalsReceptors, SomatostatinFluorodeoxyglucose F18RadiopharmaceuticalsReceptors, Somatostatinatherosclerosisgiant cell arteritisinflammationmolecular imagingsomatostatin receptorTakayasu arteritis

Identifiers

PMID36697134
PMCPMC9883634
OpenAlexW4317797106

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.