Evidence map›Paper›PMID 36696569›Full record

ReviewAnnual review of immunology2023

Immune-Epithelial Cross Talk in Regeneration and Repair.

Laure Guenin-Mace, Piotr Konieczny, Shruti Naik

Abstract readReview
In one paragraph

Review in Annual review of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. Review
  3. Epithelial-Dermal Immune Memory: TrackingInternational journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Article
  12. Review
  13. Review
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  16. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laure Guenin-MaceDepartment of Pathology, NYU Langone Health, New York, NY, USA; email: shruti.naik@nyulangone.org.
Piotr KoniecznyDepartment of Pathology, NYU Langone Health, New York, NY, USA; email: shruti.naik@nyulangone.org.
Shruti NaikDepartment of Pathology, NYU Langone Health, New York, NY, USA; email: shruti.naik@nyulangone.org.

Funding

Mechanisms of immune-epithelial crosstalk in tissue repairR01AI168462 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Shruti Naik · 2022 to 2026
$3.1M
Decoding microbe-epithelial stem cell interactions in health and diseaseDP2AR079173 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NAIK, SHRUTI · 2020 to 2020
$2.5M
NIAID NIH HHS R01 AI168462NIAMS NIH HHS DP2 AR079173
6 · The paper itself

Abstract

The epithelial tissues that line our body, such as the skin and gut, have remarkable regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier function, these tissues have also evolved sophisticated repair mechanisms to swiftly heal and limit the penetration of harmful agents following injury. Researchers now appreciate that epithelial regeneration and repair are not autonomous processes but rely on a dynamic cross talk with immunity. A wealth of clinical and experimental data point to the functional coupling of reparative and inflammatory responses as two sides of the same coin. Here we bring to the fore the immunological signals that underlie homeostatic epithelial regeneration and restitution following damage. We review our current understanding of how immune cells contribute to distinct phases of repair. When unchecked, immune-mediated repair programs are co-opted to fuel epithelial pathologies such as cancer, psoriasis, and inflammatory bowel diseases. Thus, understanding the reparative functions of immunity may advance therapeutic innovation in regenerative medicine and epithelial inflammatory diseases.

Indexed as

Inflammatory Bowel DiseasesSkinAnimalsEpitheliumHumansRegenerationepitheliumimmunityinflammatory diseaseregenerationrepairstem cells

Identifiers

PMID36696569
PMCPMC10750769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.