ArticleScience advances2023
Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 102 citations in OpenAlex.
- Pacin, a novel bacteriocin fromMicrobiology spectrum · 2026Article
- Antimicrobial Cyclic Peptidomimetics.Macromolecular rapid communications · 2026Article
- AI-guided precise design of antimicrobial polymers through high-throughput screening technology on an automated platform.Bioactive materials · 2026Article
- Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis.Nature communications · 2025Article
- Heteroaryl Bishydrazono Nitroimidazoles: A Unique Structural Skeleton with Potent Multitargeting Antibacterial Activity.International journal of molecular sciences · 2025Article
- Understanding interspecies drug response variations between human and rodent P2X7 receptors.Nature communications · 2025Article
- Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria.Nature communications · 2025Article
- Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing.Bioactive materials · 2025Article
- Poly(hexamethylene guanidine): An Effective Compound in Tackling Persistent Bacterial Subpopulations.Microorganisms · 2025Article
- Optimizing therapeutic efficacy of antifungal peptides via strategic terminal amino acid modification.Journal of advanced research · 2025Article
- Self-assembling peptide with dual function of cell penetration and antibacterial as a nano weapon to combat intracellular bacteria.Science advances · 2025Article
- Article
- Antibacterial activities of oregano essential oils and their active components.Frontiers in pharmacology · 2025Article
- Development of Low-Toxicity Antimicrobial Polycarbonates Bearing Lysine Residues.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- A Rhein-Based Derivative TargetsAntibiotics (Basel, Switzerland) · 2024Article
- Helicity-directed recognition of bacterial phospholipid via radially amphiphilic antimicrobial peptides.Science advances · 2024Article
- Prokaryotic Expression, Purification, and Biological Properties of a Novel Bioactive Protein (PFAP-1) fromMarine drugs · 2024Article
- Combinatorial discovery of antibacterialsChemical science · 2024Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-resistant bacterial infections have caused serious threats to human health and call for effective antibacterial agents that have low propensity to induce antimicrobial resistance. Host defense peptide-mimicking peptides are actively explored, among which poly-β-l-lysine displays potent antibacterial activity but high cytotoxicity due to the helical structure and strong membrane disruption effect. Here, we report an effective strategy to optimize antimicrobial peptides by switching membrane disrupting to membrane penetrating and intracellular targeting by breaking the helical structure using racemic residues. Introducing β-homo-glycine into poly-β-lysine effectively reduces the toxicity of resulting poly-β-peptides and affords the optimal poly-β-peptide, βLys
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.