ArticleScience translational medicine2023
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.
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Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
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Who cites it
35 citing papers in PubMed.
- CXCR6+ CD127- Tr1 cells balance immunity and persistence in Plasmodium falciparum infection.The Journal of clinical investigation · 2026Article
- Circulating T-follicular helper and type I regulatory T cells have overlapping phenotypes inbioRxiv : the preprint server for biology · 2026Article
- NK cell cytotoxicity is transiently enhanced during acute malaria and modulated by the host microenvironment.JCI insight · 2026Article
- Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles.American journal of human genetics · 2026Article
- Latent cytomegalovirus disrupts innate NK cell responses to P. falciparum and impairs parasite control in first infection in adults.PLoS pathogens · 2026Article
- Cellular and molecular interactions underlying the peripheral immune responses to blood-stage malaria infections.ImmunoHorizons · 2026Review
- EBV Type 1 versus Type 2: A determinant of NK cell anti-tumor activity in Burkitt lymphoma.bioRxiv : the preprint server for biology · 2026Article
- Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells.PLoS pathogens · 2026Article
- Altered natural killer cell function in children with severe malaria.ImmunoHorizons · 2026Article
- Cerebrospinal Fluid Mononuclear Cell Phenotype and Activation Predictors of 2-Week and 1-Year Survival Among Persons With HIV-Associated Cryptococcal Meningitis.The Journal of infectious diseases · 2025Article
- Age is an intrinsic driver of inflammatory responses to malaria.Nature communications · 2025Article
- CXCR6bioRxiv : the preprint server for biology · 2025Article
- Article
- Fc-Afucosylation of VAR2CSA-Specific Immunoglobulin G and Clinical Immunity to Placental Plasmodium falciparum Malaria.The Journal of infectious diseases · 2025Article
- Phenotype and function of IL-10-producing NK cells in individuals with malaria experience.JCI insight · 2025Article
- Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses.Science immunology · 2025Article
- Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria.Nature communications · 2025Article
- Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications.Theranostics · 2025Review
- Breaking the bind: PfEMP1-specific antibodies in cerebral malaria.Frontiers in immunology · 2025Review
- Natural killer cell memory: challenges and opportunities for cancer immunotherapy.Cancer biology & therapy · 2024Review
Corrections and comments
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Authors and funding
31 authors.
Maureen TyDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5108-7714
Shenghuan SunBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Perri C CallawayDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5135-0698
John RekInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0003-4063-0763
Kathleen D PressDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6548-7513
Kattria van der PloegDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3183-3190
Jason NidefferDepartment of Medicine, Stanford University, Stanford, CA, USA.
Zicheng HuBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4168-1725
Sandy KlemmDepartment of Genetics, Stanford University, Stanford, CA, USA.
William GreenleafDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1409-3095
Michele DonatoInstitute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9968-6027
Stephen TukwasibweInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0002-6469-6516
Emmanuel ArinaitweInfectious Diseases Research Collaboration, Kampala, Uganda.
Felistas NankyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Kenneth MusinguziInfectious Diseases Research Collaboration, Kampala, Uganda.
Dean AndrewQueensland Institute for Medical Research, Queensland, Australia.ORCID 0000-0001-6528-5439
Lauren de la ParteDepartment of Medicine, Stanford University, Stanford, CA, USA.
Diego Martinez MoriDepartment of Medicine, Stanford University, Stanford, CA, USA.
Savannah N LewisDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7082-6914
Saki TakahashiDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5413-5507
Isabel Rodriguez-BarraquerDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6784-1021
Bryan GreenhouseDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0287-9111
Catherine BlishDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6946-7627
P J UtzDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1181-1565
Purvesh KhatriInstitute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4143-4708
Grant DorseyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0740-0317
Moses KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Michelle BoyleQueensland Institute for Medical Research, Queensland, Australia.ORCID 0000-0002-0268-232X
Margaret FeeneyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2515-2989
Isaac SsewanyanaInfectious Diseases Research Collaboration, Kampala, Uganda.
Prasanna JagannathanDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6305-758X
Funding
Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joaniter Immaculate Nankabirwa · 2010 to 2026
$29.3MThe role of γδ T cells in fetal and infant immune defense against malariaR01AI093615 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEENEY, MARGARET E · 2011 to 2025
$9.1MComputational models of naturally acquired immunity to falciparum malariaU01AI150741 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUTTE, ATUL J, GREENHOUSE, BRYAN R · 2020 to 2024
$7.4MEMERGING INFECTIOUS DISEASEST32AI007502 · NIAID · STANFORD UNIVERSITY · PI Prasanna Jagannathan, DAVID A. RELMAN · 1995 to 2026
$6.8MMentoring Translational Researchers for Careers in Pediatric Global HealthK24AI113002 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEENEY, MARGARET E · 2014 to 2023
$1.9MMentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6MNIAID NIH HHS K24 AI113002NIAID NIH HHS K24 AI144048NIAID NIH HHS R01 AI093615NIAID NIH HHS T32 AI007502NIAID NIH HHS U01 AI150741NIAID NIH HHS U19 AI089674
Abstract
Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan children. Repeated malaria exposure was associated with expansion of an atypical, CD56
Indexed as
Killer Cells, NaturalMalariaCD56 AntigenChildHumansPlasmodium falciparumReceptors, FcCD56 AntigenReceptors, Fc
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