Evidence map›Paper›PMID 36696461›Full record

ArticleBlood advances2023

SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells.

Yannis Hara, Viktor T Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard, Alexandra Hicks, David R Light

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yannis HaraImmunology and Inflammation, Sanofi, Cambridge, MA.ORCID 0000-0002-2084-971X
Viktor T LemgartTidal Therapeutics, Cambridge, MA.
Nis HallandIntegrated Drug Discovery, Sanofi, Frankfurt, Germany.ORCID 0000-0003-1684-9036
Kiana MahdavianiSickle Cell Center of Excellence, Boston University Medical Center, Boston, MA.
Jean-Antoine RibeilSickle Cell Center of Excellence, Boston University Medical Center, Boston, MA.ORCID 0000-0002-4549-4783
Samuel LessardRare Blood Disorders, Sanofi, Waltham, MA.ORCID 0000-0002-1010-2268
Alexandra HicksImmunology and Inflammation, Sanofi, Cambridge, MA.
David R LightRare Blood Disorders, Sanofi, Waltham, MA.ORCID 0000-0002-2967-6974
Sanofi (United States) · USBoston University · USSanofi (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellFetal HemoglobinErythrocytes, AbnormalErythroid CellsHumansPolymerizationFetal Hemoglobin

Identifiers

PMID36696461
PMCPMC10225891
OpenAlexW4317987841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.