ArticlePLoS neglected tropical diseases2023
Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles.
Article in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Stage-aware transcriptomics reveals selective haplotype persistence in short-termbioRxiv : the preprint server for biology · 2026Article
- Population genomics of Plasmodium ovale species in sub-Saharan Africa.Nature communications · 2024Article
- Immune gene expression changes more during a malaria transmission season than between consecutive seasons.Microbiology spectrum · 2024Article
- Population genomics ofbioRxiv : the preprint server for biology · 2024Article
- Gene expression analyses reveal differences in children's response to malaria according to their age.Nature communications · 2024Article
- Evaluation of the Performance of Rapid Diagnostic Tests for Malaria Diagnosis and Mapping of DifferentInternational journal of environmental research and public health · 2024Article
- Gene expression analyses reveal differences in children's response to malaria according to their age.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
19 authors at 2 institutions in 2 countries.
Funding
Abstract
Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum and P. ovale are endemic to Mali and cause clinical malaria, with P. falciparum infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during infections with either P. falciparum or P. ovale, and characterized the host and parasite gene expression profiles. We found that human gene expression varies more between individuals than according to the parasite species causing the infection, while parasite gene expression profiles cluster by species. Additionally, we characterized DNA polymorphisms of the parasites directly from the RNA-seq reads and found comparable levels of genetic diversity in both species, despite dramatic differences in prevalence. Our results provide unique insights into host-pathogen interactions during malaria infections and their variations according to the infecting Plasmodium species, which will be critical to develop better elimination strategies against all human Plasmodium parasites.
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