SynthesisPloS one2023
Maternal and neonatal outcomes of singleton versus twin pregnancies complicated by gestational diabetes mellitus: A systematic review and meta-analysis.
Synthesis in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Gestational Diabetes Mellitus and Adverse Maternal and Neonatal Health Outcomes: an Umbrella review of Meta-Analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Gestational diabetes in multifetal versus singleton pregnancies: A multicenter cohort study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Nomogram model for predicting spontaneous preterm birth in twin pregnancies: a case-control study.BMC pregnancy and childbirth · 2026Article
- Gestational Diabetes Mellitus in Singleton and Twin Pregnancies: A Comparison of Fetomaternal Outcomes.Diagnostics (Basel, Switzerland) · 2026Article
- Attenuated Impact of Gestational Diabetes Mellitus (GDM) With Hypertensive Disorders of Pregnancy (HDP) on Adverse Pregnancy Outcomes in Twin Versus Singleton Gestations: A Single-Center Real-World Study.Journal of diabetes research · 2026Article
- Identifying the impact and critical windows of extreme temperatures on the risk of gestational diabetes mellitus in twin pregnancies.Journal of endocrinological investigation · 2025Article
- The Impact of the First Trimester and Second Trimester Temperature, Air Pollutants, and Seasonal Variations on the Risk of Gestational Diabetes Mellitus in Twin Pregnancies.Journal of diabetes research · 2025Article
- Obstetric and neonatal outcomes in the management of twin pregnancies with gestational diabetes using the IADPSG criteria for singleton pregnancies.BMC pregnancy and childbirth · 2024Article
- Development and validation of a prenatal predictive nomogram for the risk of NICU admission in infants born to Chinese mothers over 35 years of age: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Maternal and neonatal outcomes of twin pregnancies complicated by gestational diabetes mellitus.Endocrine · 2024Article
- Twin Pregnancy Complicated by Gestational Diabetes Mellitus: Maternal and Neonatal Outcomes.Journal of the Endocrine Society · 2024Article
- Self-Care Behaviors in Pregnant Women with Gestational Diabetes.Galen medical journal · 2024Review
- Characteristics of the oral glucose tolerance test in women with different pre-pregnancy body mass index and the effect of gestational diabetes mellitus on twin pregnancy outcomes.Clinics (Sao Paulo, Brazil) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is limited evidence exploring the maternal and neonatal complications of gestational diabetes mellitus (GDM) following singleton or twin pregnancies. Further, there have been no reviews completed examining the possible risk factors associated with GDM in singleton compared to twin pregnancies. This study assesses the impact of GDM in singleton and twin pregnancies on maternal and neonatal outcomes.
methodsFrom 1954 to December 2021, a thorough literature search was conducted in the EMBASE, Cochrane, MEDLINE, ScienceDirect, and Google Scholar databases and search engines. The risk of bias was calculated using the Newcastle Ottawa (NO) scale. A random-effects model was applied and interpreted as pooled odds ratio (OR) with 95% confidence intervals (CI).
resultsEight studies satisfied the inclusion criteria, with the quality of most studies being good to satisfactory. The risk of caesarean section (pooled OR = 0.32; 95%CI: 0.22 to 0.46), small-for-gestational age (SGA) neonates (pooled OR = 0.40; 95%CI: 0.19 to 0.84), preterm delivery (pooled OR = 0.07; 95%CI: 0.06 to 0.09), respiratory morbidity (pooled OR = 0.26; 95%CI: 0.19 to 0.37), neonatal hyperbilirubinemia (pooled OR = 0.19; 95%CI: 0.10 to 0.40), and NICU admission (pooled OR = 0.18; 95%CI: 0.14 to 0.25) was significantly lower in singleton pregnancies with GDM than in twin pregnancies with GDM.
conclusionMaternal outcomes like caesarean section and neonatal outcomes like SGA neonates, preterm delivery, respiratory morbidity, hyperbilirubinemia, and NICU admission were significantly greater in twin pregnancies with GDM. It is important for clinicians and policymakers to focus intervention strategies on twin pregnancies with GDM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.