Evidence map›Paper›PMID 36696197›Full record

ArticleJournal of thrombosis and haemostasis : JTH2023

Pre-existing anti-factor VIII immunity alters therapeutic platelet-targeted factor VIII engraftment following busulfan conditioning through cytotoxic CD8 T cells.

Weiqing Jing, Christina K Baumgartner, Feng Xue, Jocelyn A Schroeder, Qizhen Shi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Weiqing JingBlood Research Institute, Versiti, Milwaukee, Wisconsin, USA.
Christina K BaumgartnerBlood Research Institute, Versiti, Milwaukee, Wisconsin, USA.
Feng XueDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jocelyn A SchroederBlood Research Institute, Versiti, Milwaukee, Wisconsin, USA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Qizhen ShiBlood Research Institute, Versiti, Milwaukee, Wisconsin, USA; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Children's Research Institute, Children's Wisconsin, Milwaukee, Wisconsin, USA; Midwest Athletes Against Childhood Cancer (MACC) Fund Research Center Milwaukee, Wisconsin, USA. Electronic address: qshi@mcw.edu.
Medical College of Wisconsin · USVersiti Blood Center of Wisconsin · USChildren's Hospital of Wisconsin · US

Funding

Platelet-Derived FVIII Gene Therapy of Hemophilia AR01HL102035 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Qizhen Shi · 2010 to 2026
$7.0M
NHLBI NIH HHS R01 HL102035
6 · The paper itself

Abstract

backgroundWe previously demonstrated that busulfan preconditioning enabled sustained therapeutic platelet-derived factor VIII (FVIII) expression in naïve FVIII

objectiveIn this study, we aimed to describe the mechanism of this platelet-FVIII loss.

methodsWe monitored platelet-FVIII expression in FVIII

resultsPlatelet-FVIII expression was sustained in 2bF8

conclusionPre-existng immunity can alter the engraftment of 2bF8

Indexed as

Hemophilia AHemostaticsAnimalsBlood PlateletsBusulfanCD8-Positive T-LymphocytesInterferon-gammaMiceMice, KnockoutBusulfanHemostaticsInterferon-gammagene therapyhemophilia Ainhibitorsplateletspreconditioning

Identifiers

PMID36696197
PMCPMC11249136
OpenAlexW4317940630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.