Evidence map›Paper›PMID 36696047›Full record

ArticleCell and tissue banking2024

Decellularized cryopreserved human pericardium: a validation study towards tissue bank practice.

Giulia Montagner, Antonia Barbazza, Andrea Tancredi Lugas, Mara Terzini, Gianpaolo Serino, Cristina Bignardi, Matilde Cacciatore, Vladimiro L Vida, Massimo A Padalino, Diletta Trojan

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Cell and tissue banking, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Pericardium decellularization in a one-day, two-step protocol.Molecular and cellular biochemistry · 2025
    Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Giulia MontagnerFondazione Banca Dei Tessuti del Veneto Onlus, Treviso, Italy. gmontagner@fbtv-treviso.org.ORCID http://orcid.org/0000-0003-4978-8209
Antonia BarbazzaFondazione Banca Dei Tessuti del Veneto Onlus, Treviso, Italy.
Andrea Tancredi LugasPolitoBIOMed Lab, Politecnico Di Torino, Turin, Italy.
Mara TerziniPolitoBIOMed Lab, Politecnico Di Torino, Turin, Italy.
Gianpaolo SerinoPolitoBIOMed Lab, Politecnico Di Torino, Turin, Italy.
Cristina BignardiPolitoBIOMed Lab, Politecnico Di Torino, Turin, Italy.
Matilde CacciatoreUnità Operativa Complessa Anatomia Patologica, AULSS2 Marca Trevigiana, Ospedale Di Treviso, Treviso, Italy.
Vladimiro L VidaPediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Massimo A PadalinoPediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Diletta TrojanFondazione Banca Dei Tessuti del Veneto Onlus, Treviso, Italy.
Politecnico di Torino · ITVeneto Eye Bank Foundation · ITUniversity of Padua · ITAULSS 2 Marca Trevigiana · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pericardial patches are currently used as reconstructive material in cardiac surgery for surgical treatment of cardiac septal defects. Autologous pericardial patches, either treated with glutaraldehyde or not, can be used as an alternative to synthetic materials or xenograft in congenital septal defects repair. The availability of an allogenic decellularized pericardium could reduce complication during and after surgery and could be a valid alternative. Decellularization of allogenic tissues aims at reducing the immunogenic reaction that might trigger inflammation and tissue calcification over time. The ideal graft for congenital heart disease repair should be biocompatible, mechanically resistant, non-immunogenic, and should have the ability to growth with the patients. The aim of the present study is the evaluation of the efficacy of a new decellularization protocol of homologous pericardium, even after cryopreservation. The technique has proven to be suitable as a tissue bank procedure and highly successful in the removal of cells and nucleic acids content, but also in the preservation of collagen and biomechanical properties of the human pericardium.

Indexed as

CryopreservationPericardiumTissue BanksBiomechanical PhenomenaCollagenDecellularized Extracellular MatrixHumansCollagenDecellularized Extracellular MatrixAllograftCardiac septal defectsDecellularizationPericardiumTissue bank

Identifiers

PMID36696047
PMCPMC11142958
OpenAlexW4317938422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.