Evidence map›Paper›PMID 36695971›Full record

ArticleBrain imaging and behavior2023

Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.

Jocelyn Hoye, Jose Key, Bart de Laat, Kelly P Cosgrove, Suchitra Krishnan-Sarin, Xenophon Papademetris, Evan D Morris

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jocelyn HoyeYale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA. Jocelyn.hoye@yale.edu.
Jose KeyDepartment of Biomedical Engineering, Yale School of Medicine, New Haven, CT, USA.
Bart de LaatYale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA.
Kelly P CosgroveYale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA.
Suchitra Krishnan-SarinDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Xenophon PapademetrisDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Evan D MorrisYale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA.
Yale University · US

Funding

Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
PET imaging of Naltrexone Occupancy of Kappa Receptors in Heavy DrinkersR01AA021818 · NIAAA · YALE UNIVERSITY · PI KRISHNAN-SARIN, SUCHITRA, MORRIS, EVAN D · 2013 to 2019
$3.4M
NCATS NIH HHS UL1 TR000142NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R01 AA021818
6 · The paper itself

Abstract

Striatal kappa opioid receptor (KOR) availability in 48 subjects with Alcohol Use Disorder (AUD) was previously found to be associated with degree of drinking following a week of naltrexone treatment (de Laat et al. Biological Psychiatry, 86(11), 864-871, 2019). The purpose of the current study was to determine if spectral clustering applied to previously acquired KOR images (with [11C]LY2795050 PET) could identify meaningful groupings of different responses to naltrexone and to assess the robustness of the finding. Spectral clustering was applied to 6 features (regional volume of distribution values, V

Indexed as

AlcoholismNaltrexoneAlcohol DrinkingHumansMagnetic Resonance ImagingPositron-Emission TomographyReceptors, Opioid, kappaNaltrexoneReceptors, Opioid, kappaAlcohol use disorderKappa opioid receptorMachine learningPositron emission tomographySmall sample sizeSpectral clustering

Identifiers

PMID36695971
PMCPMC11815977
OpenAlexW4317910645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.