Evidence map›Paper›PMID 36695943›Full record

ArticleWiener medizinische Wochenschrift (1946)2023

Dissociation of clinical, laboratory, and bone biopsy findings in adult X-linked hypophosphatemia: a case report.

Roland Kocijan, Gabriel Tilmann Mindler, Markus Alexander Hartmann, Danial Arian Kraus, Adalbert Raimann, Jochen Zwerina

Abstract readCase Reports
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In one paragraph

Article in Wiener medizinische Wochenschrift (1946), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Roland Kocijan1st Medical Department Hanusch Hospital, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA; Trauma Centre Meidling, Heinrich-Collin-Straße 30, 1140, Vienna, Austria. roland.kocijan@osteologie.lbg.ac.at.
Gabriel Tilmann MindlerVienna Bone and Growth Center, Vienna, Austria.
Markus Alexander Hartmann1st Medical Department Hanusch Hospital, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA; Trauma Centre Meidling, Heinrich-Collin-Straße 30, 1140, Vienna, Austria.
Danial Arian Kraus1st Medical Department Hanusch Hospital, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA; Trauma Centre Meidling, Heinrich-Collin-Straße 30, 1140, Vienna, Austria.
Adalbert RaimannVienna Bone and Growth Center, Vienna, Austria.
Jochen Zwerina1st Medical Department Hanusch Hospital, Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA; Trauma Centre Meidling, Heinrich-Collin-Straße 30, 1140, Vienna, Austria.
Ludwig Boltzmann Institute of Osteology · ATMedical University of Vienna · ATOrthopaedic Hospital Speising · ATUnfallkrankenhaus Meidling · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X‑linked hypophosphatemia (XLH) is a phosphate wasting disorder. Typical serum constellations include low serum phosphate as well as high alkaline phosphatase (ALP) and fibroblast growth factor 23 (FGF-23 ) levels. Adult XLH patients usually suffer from (pseudo)fractures, enthesopathies, impaired mobility, and osteoarthritis. We report the case of a middle-aged woman with clinically mild disease, relatively balanced laboratory values, but bone non-healing of the femur post-surgery. Transiliac bone biopsy revealed pronounced osteomalacia and severe deterioration of bone microstructure. Due to the lack of XLH-typical symptoms, the patient was not substituted with calcitriol and phosphate in adulthood. Thus, laboratory findings and radiological examinations do not necessarily reflect bone metabolism in XLH. Bone biopsies should be considered in unclear cases or prior to surgery in adults with XLH.

Indexed as

Familial Hypophosphatemic RicketsOsteomalaciaAdultBiopsyBone and BonesFemaleFibroblast Growth FactorsHumansMiddle AgedPhosphatesFibroblast Growth FactorsPhosphatesBone non-healingBone turnover markersPhosphateTransiliac bone biopsyX‑linked hypophosphatemia

Identifiers

PMID36695943
OpenAlexW4318025402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.