SynthesisLung2023
Solitary Lung Nodule: CT-Guided Transthoracic Biopsy vs Transbronchial Biopsy With Endobronchial Ultrasound and Flexible Bronchoscope, a Meta-Analysis of Randomized Controlled Trials.
Synthesis in Lung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Advanced Bronchoscopic Approaches to Peripheral Pulmonary Lesions: a Narrative Review of Current and Emerging Techniques.Pulmonary therapy · 2026Review
- Use of the Ion Robot in the Diagnosis of Pulmonary Nodules: Fine Needle Aspiration Versus Cryobiopsy.Diagnostic cytopathology · 2026Article
- Bronchiectasis in Inborn Errors of Immunity: Prevalence, Predictors, and Cardiopulmonary Complications in a Genetically Characterized Cohort.Journal of clinical immunology · 2026Observational
- Diagnostic Yield and Safety of Radial Probe Endobronchial Ultrasound-Guided Transbronchial Lung Cryobiopsy with a Guide Sheath in Pulmonary Lesions < 3 cm.Diagnostics (Basel, Switzerland) · 2026Article
- Determinants of Pneumothorax and Alveolar Hemorrhage After CT-Guided Lung Biopsy.Diagnostics (Basel, Switzerland) · 2026Article
- The Contribution of Radial Endobronchial Ultrasound (EBUS) in the Diagnosis of Pulmonary Cystic Lesions.Cureus · 2026Article
- Factors Influencing Diagnostic Yield and Complication Risk in CT-Guided Transthoracic Lung Biopsy of Pulmonary Lesions: A Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Learning curve, safety and diagnostic yield of the GalaxyJournal of thoracic disease · 2026Article
- Investigating Partial Registration for Optimizing Robotic-Assisted Bronchoscopy Evaluations of Peripheral Lung Nodules (I-PROBE).CHEST pulmonary · 2026Article
- Machine learning predicts severe adverse events and salvage success of CT-guided lung biopsy after nondiagnostic transbronchial lung biopsy.European radiology · 2026Article
- Pulmonary Hemorrhage and Pneumothorax Risk During CT-Guided Lung Biopsy for Suspected Lung Cancer.Cancers · 2026Article
- Evaluation of the efficacy of different lung biopsy modalities in solitary pulmonary nodules.Frontiers in bioengineering and biotechnology · 2026Article
- Patient specific characteristics and risk of iatrogenic pneumothorax after CT-guided biopsy of the lung parenchyma.European clinical respiratory journal · 2026Article
- Outcomes of radial probe endobronchial ultrasound-guided transbronchial lung cryobiopsy using guide sheath and the target fixing technique.Translational lung cancer research · 2025Article
- Curative intent therapy of stage I-III non-small cell lung cancer: a patient-centered precision approach to assess, measure, and interpret benefits and harms.Journal of thoracic disease · 2025Article
- Computed tomography-guided percutaneous biopsy for diagnosing pulmonary nodules: a prospective, multicenter observational study.Journal of thoracic disease · 2025Article
- Clinical TNM Lung Cancer Staging: A Diagnostic Algorithm with a Pictorial Review.Diagnostics (Basel, Switzerland) · 2025Review
- Outcomes of Robot-Assisted Transbronchial Biopsies of Pulmonary Nodules: A Review.Diagnostics (Basel, Switzerland) · 2025Review
- The Role of Bronchoscopy in the Management of Lung Nodules. Is it too Early to Retire Transthoracic Needle Aspiration?The open respiratory medicine journal · 2025Review
- Active breathing coordinator combines with custom-designed puncture needle improves diagnostic accuracy of ≤20 mm pulmonary nodules under CT-guidance: a real world prospective study.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransbronchial lung biopsy with radial endobronchial ultrasound (rEBUS-TBB) and Computed tomography (CT) scan-guided transthoracic biopsy (CT-TTB) are commonly used to investigate peripheral lung nodules but high-quality data are still not clear about the diagnostic and safety profile comparison of these two modalities.
methodWe included all randomized controlled trials (RCT) comparing rEBUS-TBB with a flexible bronchoscope and CT-TTB for solitary lung nodules. Two reviewers extracted data independently on diagnostic performance and complication rates.
results170 studies were screened, 4 RCT with a total of 325 patients were included. CT-TTB had a higher diagnostic yield than rEBUS-TBB (83.45% vs 68.82%, risk difference - 0.15, 95% CI, [- 0.24, - 0.05]), especially for lesion size 1-2 cm (83% vs 50%, risk difference - 0.33, 95% CI, [- 0.51, - 0.14]). For malignant diseases, rEBUS-TBB had a diagnostic yield of 75.75% vs 87.7% of CT-TTB. rEBUS-TBB had a significant better safety profile with lower risks of pneumothorax (2.87% vs 21.43%, OR = 0.12, 95% CI [0.05-0.32]) and combined outcomes of hospital admission, hemorrhage, and pneumothorax (8.62% vs 31.81%, OR 0.21, 95% CI, [0.11-0.40]). Factors increasing diagnostic yield of rEBUS were lesion size and localization of the probe but not the distance to the chest wall and hilum.
conclusionCT-TTB had a higher diagnostic yield than rEBUS-TBB in diagnosing peripheral lung nodules, particularly for lesions from 1 to 2 cm. However, rEBUS-TBB was significantly safer with five to eight times less risk of pneumothorax and composite complications of hospital admission, hemorrhage, and pneumothorax. The results of this study only apply to flexible bronchoscopy with radial ebus without navigational technologies. More data are needed for a comparison between CT-TTB with rEBUS-TBB combined with advanced navigational modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.