Evidence map›Paper›PMID 36695842›Full record

Trial reportPsychopharmacology2023

Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration study.

Elizabeth T C Lippard, Dylan E Kirsch, Raquel Kosted, Vanessa Le, Jorge R C Almeida, Kim Fromme, Stephen M Strakowski

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04063384 (Subjective Response to Alcohol and Associated Neural Systems in Bipolar Disorder), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04063384 nacompletednot on this map

Subjective Response to Alcohol and Associated Neural Systems in Bipolar Disorder

TypeinterventionalSponsorUniversity of Texas at AustinRan2019 to 2024Enrolled60ConditionsBipolar Disorder, Alcohol Drinking, Alcohol Use DisorderArmsalcohol beverage, Placebo beverage
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Protective Effect ofPolymers · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth T C LippardDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, 1601 Trinity Street, Stop Z0600, HDB, Austin, TX, 78712, USA. elizabeth.lippard@austin.utexas.edu.
Dylan E KirschDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, 1601 Trinity Street, Stop Z0600, HDB, Austin, TX, 78712, USA.
Raquel KostedDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, 1601 Trinity Street, Stop Z0600, HDB, Austin, TX, 78712, USA.
Vanessa LeDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, 1601 Trinity Street, Stop Z0600, HDB, Austin, TX, 78712, USA.
Jorge R C AlmeidaDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, 1601 Trinity Street, Stop Z0600, HDB, Austin, TX, 78712, USA.
Kim FrommeDepartment of Psychology, University of Texas, Austin, TX, USA.
Stephen M StrakowskiDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, 1601 Trinity Street, Stop Z0600, HDB, Austin, TX, 78712, USA.
The University of Texas at Austin · US

Funding

Biological Risk Factors for the Prospective Development of Alcohol Use Disorders in Young Adults with Bipolar Disorder and Typically Developing Young AdultsR01AA030038 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Elizabeth Thomas Cox Lippard · 2023 to 2026
$2.5M
Genetic Mechanisms of Change in Trajectories of Drinking and Deviant BehaviorsR01AA020637 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI FROMME, KIM · 2012 to 2016
$2.3M
Subjective Response to Alcohol and Associated Neural Systems in Bipolar DisorderK01AA027573 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI LIPPARD, ELIZABETH THOMAS COX · 2019 to 2022
$716k
Dissecting Responses to Alcohol in Individuals with Familial Risk for Bipolar DisorderR21AA027884 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI LIPPARD, ELIZABETH THOMAS COX · 2020 to 2021
$416k
Ventral Prefrontal Network Connectivity and Alcohol Sensitivity in Bipolar Disorder and Typically Developing Young AdultsF31AA029005 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI KIRSCH, DYLAN E · 2022 to 2022
$20k
NIAAA NIH HHS F31 AA029005NIAAA NIH HHS F31AA029005NIAAA NIH HHS K01 AA027573NIAAA NIH HHS K01AA027573NIAAA NIH HHS R01 AA020637NIAAA NIH HHS R01AA020637NIAAA NIH HHS R01 AA030038NIAAA NIH HHS R21 AA027884NIAAA NIH HHS R21AA027884
6 · The paper itself

Abstract

Limited data exists on mechanisms contributing to elevated risk for alcohol use disorder (AUD) in bipolar disorder. Variation in subjective response to alcohol may relate to alcohol use and risk for AUD. This study used a randomized, placebo-controlled, cross-over, within-subjects design to investigate differences in subjective response to alcohol in 50 euthymic young adults (n = 24 with and n = 26 without bipolar disorder type I). Eighty-three percent of participants with bipolar disorder were medicated. Participants completed assessments of clinical history, alcohol expectancies, and recent alcohol use. Participants were dosed to a .08 g% breath alcohol concentration. The placebo condition occurred on a separate counter-balanced day. Subjective response to alcohol was investigated at similar time points during both conditions. Group, condition, and group-by-condition interactions were modeled, with condition and time of subjective response assessment as repeated within-subject variables, and subjective response to alcohol as the dependent variable. Greater stimulating effects and liking of alcohol were reported in people with bipolar disorder (group-by-condition interactions, p < .05) than healthy young adults. While young adults with bipolar disorder reported anticipating feeling less "mellow/relaxed" when drinking (p = .02), during both beverage conditions they reported feeling more "mellow/relaxed" (main effect of group, p = .006). Feeling more "mellow/relaxed" during the alcohol condition related to greater recent alcohol use in bipolar disorder (p = .001). Exploratory analyses suggested anticonvulsants and sedatives/antihistamines may relate to differences in subjective response to alcohol in bipolar disorder. Results suggest young adults with bipolar disorder may differ in alcohol expectancies and experience alcohol intoxication differently-with distinct relations between subjective response to alcohol and alcohol use-compared to healthy young adults.

Indexed as

AlcoholismBipolar DisorderAlcohol DrinkingData CollectionEthanolHumansYoung AdultEthanolAlcoholAlcohol expectanciesAnxietyBipolar disorderSensitivity

Identifiers

PMID36695842
PMCPMC10084816
OpenAlexW4317914939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.