Evidence map›Paper›PMID 36695735›Full record

ArticleTexas Heart Institute journal2023

Transcatheter Aortic Valve Replacement for Severe Aortic Valve Stenosis: Do Patients Experience Better Quality of Life Regardless of Gradient?

Anthony Simone, Juka S Kim, Jeanne Huchting, Asim Rafique, Ruhsen Ozcaglayan, Richard J Shemin, Olcay Aksoy, Murray H Kwon

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Article in Texas Heart Institute journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anthony SimoneDepartment of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Juka S KimDepartment of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Jeanne HuchtingDepartment of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Asim RafiqueDepartment of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Ruhsen OzcaglayanDepartment of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Richard J SheminDepartment of Cardiac Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Olcay AksoyDepartment of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Murray H KwonDepartment of Cardiac Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAortic valve replacement improves survival for patients with low-gradient aortic valve stenosis, but there is a paucity of data on postoperative quality of life for this population.

methodsIn a single-center retrospective analysis of 304 patients with severe aortic valve stenosis who underwent transcatheter aortic valve replacement, patients were divided into 4 groups based on mean pressure gradient, left ventricular ejection fraction, and stroke volume index. Using the Kansas City Cardiomyopathy Questionnaire-12, quality of life was assessed immediately before and 1 month after transcatheter aortic valve replacement.

resultsMost patients in the low-flow, low-gradient group were men; this group had higher relative rates of cardiovascular disease and type 2 diabetes than the paradoxical low-flow, low-gradient group; the normal-flow, low-gradient group; and the high-gradient group. All-cause mortality did not differ significantly among the groups at 1 month after surgery, and all groups experienced a significant improvement in quality-of-life scores after surgery. The mean improvement was 27 points in the low-flow, low-gradient group, 25 points in the paradoxical low-flow, low-gradient group, 30 points in the normal-flow, low-gradient group, and 30 points in the high-gradient group (all P < .001).

conclusionQuality of life improves significantly across all subgroups of aortic valve stenosis after trans-catheter aortic valve replacement, regardless of flow characteristics or aortic valve gradients.

Indexed as

Aortic Valve StenosisDiabetes Mellitus, Type 2Transcatheter Aortic Valve ReplacementAortic ValveFemaleHumansMaleQuality of LifeRetrospective StudiesSeverity of Illness IndexStroke VolumeTreatment OutcomeVentricular Function, LeftAortic valve stenosisquality of lifesurveys and questionnairestranscatheter aortic valve replacement

Identifiers

PMID36695735
PMCPMC9969767

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