Evidence map›Paper›PMID 36695696›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023

Honoring the gift: The transformative potential of transplant-declined human organs.

Claire Albert, Matthew Harris, Jenna DiRito, Audrey Shi, Christopher Edwards, Lauren Harkins, Taras Lysyy, Sanjay Kulkarni, David C Mulligan, Sarah A Hosgood and 6 more

Open access · greenAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Revealing the potential of non-transplanted donor organs: a comparative analysis in the Eurotransplant region.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  3. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Claire AlbertYale University, Department of Biomedical Engineering, New Haven, Connecticut, USA.
Matthew HarrisYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
Jenna DiRitoYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
Audrey ShiYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
Christopher EdwardsYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
Lauren HarkinsYale University, Department of Biomedical Engineering, New Haven, Connecticut, USA.
Taras LysyyYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
Sanjay KulkarniYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
David C MulliganYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
Sarah A HosgoodDepartment of Surgery, University of Cambridge, and Cambridge NIHR Biomedical Research Centre, Cambridge, UK.
Christopher J E WatsonDepartment of Surgery, University of Cambridge, and Cambridge NIHR Biomedical Research Centre, Cambridge, UK.
Peter J FriendUniversity of Oxford, Nuffield Department of Surgical Sciences and the Oxford Transplant Centre, Oxford, UK.
Michael L NicholsonDepartment of Surgery, University of Cambridge, and Cambridge NIHR Biomedical Research Centre, Cambridge, UK.
Danielle HaakinsonYale School of Medicine, Department of Surgery, New Haven, Connecticut, USA.
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge, and Cambridge NIHR Biomedical Research Centre, Cambridge, UK. Electronic address: ks10014@cam.ac.uk.
Gregory T TietjenYale University, Department of Biomedical Engineering, New Haven, Connecticut, USA; Yale School of Medicine, Department of Surgery, New Haven, Connecticut, USA. Electronic address: gregory.tietjen@yale.edu.
Yale University · USUniversity of Cambridge · GBNuffield Orthopaedic Centre · GB

Funding

Human and Translational Immunology Training ProgramT32AI155387 · NIAID · YALE UNIVERSITY · PI Joseph Edgar Craft, Kevan C Herold · 2021 to 2026
$2.6M
Mechanisms and Ex Vivo Repair of Cold-Storage Injury in Human Kidney AllograftsR01DK124420 · NIDDK · YALE UNIVERSITY · PI KULKARNI, SANJAY, POBER, JORDAN S · 2020 to 2024
$2.5M
Redefining the limits of tolerable warm ischemia in deceased donor kidneysR21DK128662 · NIDDK · YALE UNIVERSITY · PI TIETJEN, GREGORY T · 2021 to 2022
$461k
NIAID NIH HHS T32 AI155387NIDDK NIH HHS R01 DK124420NIDDK NIH HHS R21 DK128662
6 · The paper itself

Abstract

For decades, transplantation has been a life-saving treatment for those fortunate enough to gain access. Nevertheless, many patients die waiting for an organ and countless more never make it onto the waitlist because of a shortage of donor organs. Concurrently, thousands of donated organs are declined for transplant each year because of concerns about poor outcomes post-transplant. The decline of any donated organ-even if medically justified-is tragic for both the donor family and potential recipients. In this Personal Viewpoint, we discuss the need for a new mindset in how we honor the gift of organ donation. We believe that the use of transplant-declined human organs in translational research has the potential to hasten breakthrough discoveries in a multitude of scientific and medical areas. More importantly, such breakthroughs will allow us to properly value every donated organ. We further discuss the many practical challenges that such research presents and offer some possible solutions based on experiences in our own research laboratories. Finally, we share our perspective on what we believe are the necessary next steps to ensure a future where every donated organ realizes its full potential to impact the lives of current and future patients.

Indexed as

Organ TransplantationTissue and Organ ProcurementHumansTissue DonorsWaiting Listsbasic (laboratory) research/sciencedonors and donationeditorial/personal viewpointeducationguidelinesorgan perfusion and preservationorgan transplantation in general

Identifiers

PMID36695696
PMCPMC12198687
OpenAlexW4313701350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.