Evidence map›Paper›PMID 36695630›Full record

ArticleJournal of medicinal chemistry2023

Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery.

Baljinder Singh, Amrita Sharma, Naresh Gunaganti, Mitch Rivers, Pradip K Gadekar, Brady Greene, Michael Chichioco, Carlos E Sanz-Rodriguez, Courtney Fu, Catherine LeBlanc and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. A nucleosome switch primes Hepatitis B Virus infection.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Baljinder SinghDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0003-2828-5768
Amrita SharmaDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, Georgia 30144, United States.
Naresh GunagantiDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Mitch RiversDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Pradip K GadekarDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0002-9129-8812
Brady GreeneDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Michael ChichiocoDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Carlos E Sanz-RodriguezCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-6759-1955
Courtney FuDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Catherine LeBlancDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Erin BurchfieldDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Nyle SharifDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Benjamin HoffmanCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, United States.
Gaurav KumarDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, Georgia 30144, United States.
Andrei PurmalIncuron Inc., Buffalo, New York 14203, United States.
Kojo Mensa-WilmotDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, Georgia 30144, United States.
Michael P PollastriDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0001-9943-7197
Northeastern University · USUniversity of Georgia · USKennesaw State University · US

Funding

Optimization and Modes of Action of NEU-4438, a New Anti-trypanosome Lead DrugR01AI124046 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI, MENSA-WILMOT, KOJO A. · 2016 to 2025
$6.0M
Curaxin-137, A New Lead for Anti-Trypanosome Drug Discovery - Resubmission - 1R01AI126311 · NIAID · UNIVERSITY OF GEORGIA · PI HAJDUK, STEPHEN L, POLLASTRI, MICHAEL P · 2017 to 2020
$2.7M
NIAID NIH HHS R01 AI124046NIAID NIH HHS R01 AI126311
6 · The paper itself

Abstract

The carbazole CBL0137 (

Indexed as

Trypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasis, AfricanAnimalsCarbazolesDrug DiscoveryHumansMiceCarbazolesCBLC137Trypanocidal Agents

Identifiers

PMID36695630
PMCPMC9923759
OpenAlexW4317938403

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.