Evidence map›Paper›PMID 36695578›Full record

ArticleMicrobiology spectrum2023

Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection.

Maria I Costafreda, Silvia Sauleda, Mar Riveiro-Barciela, Angie Rico, Meritxell Llorens-Revull, Susana Guix, Rosa M Pintó, Albert Bosch, Francisco Rodríguez-Frías, Ariadna Rando and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Differential miRNA signatures in Hepatitis E Virus Infection: Insights into acute, chronic, and pregnancy-related outcomes.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Maria I CostafredaBlood and Tissue Bank of Catalonia (Banc de Sang i Teixits de Catalunya), Transfusion Safety Laboratory, Barcelona, Spain.ORCID 0000-0002-3114-3034
Silvia SauledaBlood and Tissue Bank of Catalonia (Banc de Sang i Teixits de Catalunya), Transfusion Safety Laboratory, Barcelona, Spain.
Mar Riveiro-BarcielaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREhd), Instituto de Salud Carlos III, Madrid, Spain.
Angie RicoBlood and Tissue Bank of Catalonia (Banc de Sang i Teixits de Catalunya), Transfusion Safety Laboratory, Barcelona, Spain.
Meritxell Llorens-RevullCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREhd), Instituto de Salud Carlos III, Madrid, Spain.
Susana GuixEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Safety, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-1588-3198
Rosa M PintóEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Safety, University of Barcelona, Barcelona, Spain.ORCID 0000-0003-1382-6648
Albert BoschEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Safety, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-8111-9059
Francisco Rodríguez-FríasCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREhd), Instituto de Salud Carlos III, Madrid, Spain.
Ariadna RandoCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREhd), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0003-4555-7286
Maria PironBlood and Tissue Bank of Catalonia (Banc de Sang i Teixits de Catalunya), Transfusion Safety Laboratory, Barcelona, Spain.
Marta BesBlood and Tissue Bank of Catalonia (Banc de Sang i Teixits de Catalunya), Transfusion Safety Laboratory, Barcelona, Spain.
Instituto de Salud Carlos III · ESUniversitat de Barcelona · ESBanc de Sang i Teixits · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenic mechanisms determining the diverse clinical outcomes of HEV infection (e.g., self-limiting versus chronic or symptomatic versus asymptomatic) are not yet understood. Because specific microRNA signatures during viral infection inform the cellular processes involved in virus replication and pathogenesis, we investigated plasma microRNA profiles in 44 subjects, including patients with symptomatic acute (AHE,

Indexed as

Hepatitis EHepatitis E virusMicroRNAsAntiviral AgentsHumansImmunoglobulin GImmunoglobulin MAntiviral AgentsImmunoglobulin GImmunoglobulin MMicroRNAsdiagnosticshepatitis E virusinfection outcomesmicroRNAprognostic indicators

Identifiers

PMID36695578
PMCPMC9927377
OpenAlexW4317939810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.