Evidence map›Paper›PMID 36695315›Full record

ArticleJournal of the American Heart Association2023

Body Composition and Risk of Vascular-Metabolic Mortality Risk in 113 000 Mexican Men and Women Without Prior Chronic Disease.

Louisa Gnatiuc Friedrichs, Rachel Wade, Jesus Alegre-Díaz, Raúl Ramirez-Reyes, Adrián Garcilazo-Ávila, Carlos Gonzáles-Carballo, Rogelio Santacruz-Benitez, Erwin Chiquete, William Herrington, Rory Collins and 6 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Obesity accelerates cardiovascular ageing.European heart journal · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Louisa Gnatiuc FriedrichsClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health University of Oxford United Kingdom.ORCID 0000-0002-0641-2220
Rachel WadeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health University of Oxford United Kingdom.ORCID 0000-0001-9826-6322
Jesus Alegre-DíazExperimental Research Unit from the Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0001-9390-3871
Raúl Ramirez-ReyesExperimental Research Unit from the Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0001-9763-324X
Adrián Garcilazo-ÁvilaExperimental Research Unit from the Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0002-9309-782X
Carlos Gonzáles-CarballoExperimental Research Unit from the Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0001-5110-1563
Rogelio Santacruz-BenitezExperimental Research Unit from the Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0002-5688-3629
Erwin ChiqueteInstituto Nacional de Ciencias Médicas y de la Nutrición, Salvador Zubirán Hospital Mexico City Mexico.ORCID 0000-0002-1142-295X
William HerringtonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health University of Oxford United Kingdom.ORCID 0000-0003-1172-8243
Rory CollinsClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health University of Oxford United Kingdom.ORCID 0000-0001-8288-8602
Richard PetoClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health University of Oxford United Kingdom.ORCID 0000-0001-8219-5339
Robert ClarkeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health University of Oxford United Kingdom.ORCID 0000-0002-9802-8241
Jaime BerumenExperimental Research Unit from the Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0001-6707-3317
Jonathan R EmbersonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health University of Oxford United Kingdom.ORCID 0000-0001-7792-9422
Pablo Kuri-MoralesSchool of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0002-0704-9507
Roberto Tapia-ConyerSchool of Medicine National Autonomous University of Mexico Mexico City Mexico.ORCID 0000-0003-3814-2904

Funding

British Heart FoundationCancer Research UKMedical Research Council MC_UU_00017/2Wellcome TrustWellcome Trust 058299/Z/99
6 · The paper itself

Abstract

Background Body-mass index is the sum of fat mass index (FMI) and lean mass index (LMI), which vary by age, sex, and impact on disease outcomes. We investigated the separate and joint relevance of FMI and LMI with vascular-metabolic causes of death in Mexican adults. Methods and Results A total of 113 025 adults aged 35 to 74 years and free from diabetes or other chronic diseases when recruited into the Mexico City Prospective Study were followed for 19 years. Cox models estimated sex-specific death rate ratios from vascular-metabolic causes after adjustment for confounders and exclusion of the first 5 years of follow-up. To account for the strong correlation between FMI and LMI, additional models estimated rate ratios associated with "residual FMI" and "residual LMI" (ie, the residuals from linear regression analyses of FMI on LMI, or vice versa). In both sexes, higher FMI and LMI were associated with higher risks of vascular-metabolic mortality. For a given (ie, fixed) level of LMI, the rate ratio (95% CI) for vascular-metabolic mortality per 1 kg/m

Indexed as

Body CompositionAdultBody Mass IndexChronic DiseaseFemaleHumansMaleMexicoProspective Studiesbody compositionMexican adultsvascular‐metabolic deaths

Identifiers

PMID36695315
PMCPMC9973642

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.