Evidence map›Paper›PMID 36695309›Full record

ArticleJournal of the American Heart Association2023

Intracranial Hemorrhage Rate and Lesion Burden in Patients With Familial Cerebral Cavernous Malformation.

Shantel Weinsheimer, Jeffrey Nelson, Adib A Abla, Nerissa U Ko, Cynthia Tsang, Obiora Okoye, Joseph M Zabramski, Amy Akers, Atif Zafar, Marc C Mabray and 5 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01764529 (Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01764529 completednot on this map

Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations

Typeobservational_patient_registrySponsorUniversity of California, San FranciscoRan2010 to 2025Enrolled789ConditionsCavernous Angioma, Familial, Cerebral Cavernous Malformations, Cerebral Cavernous Hemangioma
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Shantel WeinsheimerDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research University of California San Francisco CA.ORCID 0000-0001-7486-9110
Jeffrey NelsonDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research University of California San Francisco CA.
Adib A AblaDepartment of Neurological Surgery University of California San Francisco CA.ORCID 0000-0002-6941-2295
Nerissa U KoDepartment of Neurology University of California San Francisco CA.
Cynthia TsangDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research University of California San Francisco CA.ORCID 0000-0001-9017-6269
Obiora OkoyeDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research University of California San Francisco CA.ORCID 0000-0002-8284-6194
Joseph M ZabramskiDepartment of Neurosurgery Barrow Neurological Institute Phoenix AZ.ORCID 0000-0001-7914-4071
Amy AkersAlliance to Cure Cavernous Malformation Charlottesville VA.
Atif ZafarDepartment of Neurology University of New Mexico Albuquerque NM.ORCID 0000-0002-2738-5225
Marc C MabrayDepartment of Radiology University of New Mexico Albuquerque NM.ORCID 0000-0001-7355-6833
Blaine L HartDepartment of Radiology University of New Mexico Albuquerque NM.ORCID 0000-0001-5207-1087
Leslie MorrisonDepartment of Neurology University of New Mexico Albuquerque NM.
Charles E McCullochDepartment of Epidemiology and Biostatistics University of California San Francisco CA.ORCID 0000-0002-1279-6179
Helen KimDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research University of California San Francisco CA.ORCID 0000-0002-1937-354X
Brain Vascular Malformation Consortium Cerebral Cavernous Malformation Investigator Group *
University of California, San Francisco · USUniversity of New Mexico · USBarrow Neurological Institute · US

Funding

The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Maurizio Macaluso · 2019 to 2026
$51.2M
VCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 2009 to 2023
$20.8M
NCATS NIH HHS U2C TR002818NINDS NIH HHS U54 NS065705
6 · The paper itself

Abstract

Background Familial cerebral cavernous alformation (CCM) is an autosomal dominant disease caused by mutations in

Indexed as

Central Nervous System Vascular MalformationsHemangioma, Cavernous, Central Nervous SystemCerebral HemorrhageHumansIntracranial HemorrhagesRisk Factorscerebral cavernous malformationfamilialhemorrhagerisk factor

Identifiers

PMID36695309
PMCPMC9973654
OpenAlexW4318026322

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.