ArticleJournal of the American Heart Association2023
Phenotyping of Elderly Patients With Heart Failure Focused on Noncardiac Conditions: A Latent Class Analysis From a Multicenter Registry of Patients Hospitalized With Heart Failure.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Association between empagliflozin exposure and skeletal muscle degeneration in patients with heart failure.BMC cardiovascular disorders · 2026Observational
- Phenotyping of Patients With Clinical Features of Advanced Heart Failure: A Latent Class Analysis of a Multicenter Registry of Patients Hospitalized With Heart Failure.Journal of the American Heart Association · 2026Article
- Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty.Journal of the American Heart Association · 2026Article
- Heart failure with preserved ejection fraction: a systemic condition of comorbidities.Heart failure reviews · 2026Review
- Prognostic Impact of Annual Changes in the Geriatric Nutritional Risk Index in Malnourished Patients With Heart Failure.Circulation reports · 2025Article
- Improved Survival in Octogenarians With Heart Failure: 15-Year Cohort Study From a National Referral Center.JACC. Advances · 2025Article
- Patient-Reported Psychosocial Burdens and Quality of Life and Work Productivity Impacts Among Patients with Clinically Distinct Alopecia Areata Severity Profiles.Advances in therapy · 2025Article
- Sex-specific cardiometabolic multimorbidity, metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank.Cardiovascular diabetology · 2025Article
- Effect of basic activities of daily living independence on home discharge and long-term outcomes in patients hospitalized with heart failure.Heart and vessels · 2025Article
- Demographics and Clinical Characteristics among Patients with Distinct Psychosocial Burden Profiles Related to Vitiligo: Results of a Latent Class Analysis.Dermatology and therapy · 2025Article
- Phenotypic Trajectories From Acute to Stable Phase in Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-HFpEF Study.Journal of the American Heart Association · 2025Observational
- Determinants of health status in older patients with transthyretin cardiac amyloidosis: a prospective cohort study.Aging clinical and experimental research · 2024Article
- Treatment patterns and trajectories in patients after acute heart failure hospitalization.ESC heart failure · 2024Article
- Article
- Zero-shot interpretable phenotyping of postpartum hemorrhage using large language models.NPJ digital medicine · 2023Article
- Temporal Trends in Heart Failure Management and Outcomes: Insights From a Japanese Multicenter Registry of Tertiary Care Centers.Journal of the American Heart Association · 2023Article
- Common non-cardiovascular multimorbidity groupings and clinical outcomes in older adults with major cardiovascular disease.Journal of the American Geriatrics Society · 2023Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The burden of noncardiovascular conditions is becoming increasingly prevalent in patients with heart failure (HF). We aimed to identify novel phenogroups incorporating noncardiovascular conditions to facilitate understanding and risk stratification in elderly patients with HF. Methods and Results Data from a total of 1881 (61.2%) patients aged ≥65 years were extracted from a prospective multicenter registry of patients hospitalized for acute HF (N=3072). We constructed subgroups of patients with HF with preserved ejection fraction (HFpEF; N=826, 43.9%) and those with non-HFpEF (N=1055, 56.1%). Latent class analysis was performed in each subgroup using 17 variables focused on noncardiovascular conditions (including comorbidities, Clinical Frailty Scale, and Geriatric Nutritional Risk Index). The latent class analysis revealed 3 distinct clinical phenogroups in both HFpEF and non-HFpEF subgroups: (1) robust physical and nutritional status (Group 1: HFpEF, 41.2%; non-HFpEF, 46.0%); (2) multimorbid patients with renal impairment (Group 2: HFpEF, 40.8%; non-HFpEF, 41.9%); and (3) malnourished patients (Group 3: HFpEF, 18.0%; non-HFpEF, 12.1%). After multivariable adjustment, compared with Group 1, patients in Groups 2 and 3 had a higher risk for all-cause death over the 1-year postdischarge period (hazard ratio [HR], 2.79 [95% CI, 1.64-4.81] and HR, 2.73 [95% CI, 1.39-5.35] in HFpEF; HR, 1.96 [95% CI, 1.22-3.14] and HR, 2.97 [95% CI, 1.64-5.38] in non-HFpEF; respectively). Conclusions In elderly patients with HF, the phenomapping focused on incorporating noncardiovascular conditions identified 3 phenogroups, each representing distinct clinical outcomes, and the discrimination pattern was similar for both patients with HFpEF and non-HFpEF. This classification provides novel risk stratification and may aid in clinical decision making.
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