Evidence map›Paper›PMID 36695294›Full record

ArticleMagnetic resonance in medicine2023

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging.

Thomas Lindner, Divya S Bolar, Eric Achten, Frederik Barkhof, António J Bastos-Leite, John A Detre, Xavier Golay, Matthias Günther, Danny J J Wang, Sven Haller and 17 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  6. Article
  7. Review
  8. Article
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  13. Article
  14. Article
  15. Simultaneous multiple post-labelling delay ASL MRI and [European journal of nuclear medicine and molecular imaging · 2026
    Article
  16. Article
  17. Article
  18. Head to head comparison between arterial spin labelling MRI and [Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Observational
  19. Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Thomas LindnerDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-4408-2429
Divya S BolarCenter for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, San Diego, California, USA.
Eric AchtenDepartment of Radiology and Nuclear Medicine, Ghent University, Ghent, Belgium.ORCID 0000-0002-5148-4178
Frederik BarkhofDepartment of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, The Netherlands.
António J Bastos-LeiteFaculty of Medicine, University of Porto, Porto, Portugal.
John A DetreDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xavier GolayUCL Queen Square Institute of Neurology, University College London, London, UK.
Matthias GüntherUniversity of Bremen, Bremen, Germany.
Danny J J WangStevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-0840-7062
Sven HallerCIMC - Centre d'Imagerie Médicale de Cornavin, Genève, Switzerland.
Silvia IngalaDepartment of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Hans R JägerUCL Queen Square Institute of Neuroradiology, University College London, London, UK.
Geon-Ho JahngDepartment of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Meher R JuttukondaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Vera C KeilDepartment of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Hirohiko KimuraDepartment of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Mai-Lan HoRadiology, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
Maarten LequinDivision Imaging and Oncology, Department of Radiology and Nuclear Medicine, University Medical Center Utrecht and Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Xin LouDepartment of Radiology, Chinese PLA General Hospital, Beijing, China.
Jan PetrDepartment of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Nandor PinterDent Neurologic Institute, Buffalo, New York, USA.
Francesca B PizziniRadiology Institute, Department of Diagnostic and Public Health, University of Verona, Verona, Italy.
Marion SmitsDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Magdalena SokolskaDepartment of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, UK.
Greg ZaharchukStanford University, Stanford, California, USA.
Henk J M M MutsaertsDepartment of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID 0000-0003-0894-0307
on behalf of the ISMRM Perfusion Study Group

Funding

WORKSHOP ON ADVANCES IN MUSCULOSKELETAL MRIP41RR002305 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI WANG, CHENYANG · 1985 to 2011
$14.7M
Microvascular mechanisms underlying white matter lesions in older adultsK01AG070318 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JUTTUKONDA, MEHER R · 2021 to 2025
$625k
NCRR NIH HHS P41 RR002305NIA NIH HHS K01 AG070318
6 · The paper itself

Abstract

This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group to update and expand on the recommendations provided in the 2015 ASL consensus paper. Although the 2015 consensus paper provided general guidelines for clinical applications of ASL MRI, there was a lack of guidance on disease-specific parameters. Since that time, the clinical availability and clinical demand for ASL MRI has increased. This position paper provides guidance on using ASL in specific clinical scenarios, including acute ischemic stroke and steno-occlusive disease, arteriovenous malformations and fistulas, brain tumors, neurodegenerative disease, seizures/epilepsy, and pediatric neuroradiology applications, focusing on disease-specific considerations for sequence optimization and interpretation. We present several neuroradiological applications in which ASL provides unique information essential for making the diagnosis. This guidance is intended for anyone interested in using ASL in a routine clinical setting (i.e., on a single-subject basis rather than in cohort studies) building on the previous ASL consensus review.

Indexed as

Ischemic StrokeNeurodegenerative DiseasesCerebrovascular CirculationChildHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingNeuroimagingPerfusionSpin LabelsSpin Labelsarterial spin labelingclinical routine ASLperfusion

Identifiers

PMID36695294
PMCPMC10914350

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.