Evidence map›Paper›PMID 36695176›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2023

Use of Valsalva Maneuver to Detect Late-Onset Delayed Orthostatic Hypotension.

Jin-Woo Park, Luis E Okamoto, Sung-Hwan Kim, Seol-Hee Baek, Joo Hye Sung, Namjoon Jeon, Alfredo Gamboa, Cyndya A Shibao, André Diedrich, Byung-Jo Kim and 1 more

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Jin-Woo ParkDepartment of Neurology, Korea University Medicine, Seoul (J.-W.P., S.-H.K., S.-H.B., J.H.S., N.J., B.-J.K.).ORCID 0000-0001-5548-3378
Luis E OkamotoDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.-W.P., L.E.O., A.G., C.A.S., A.D., I.B.).ORCID 0000-0001-6914-7287
Sung-Hwan KimDepartment of Neurology, Korea University Medicine, Seoul (J.-W.P., S.-H.K., S.-H.B., J.H.S., N.J., B.-J.K.).ORCID 0000-0002-0778-1570
Seol-Hee BaekDepartment of Neurology, Korea University Medicine, Seoul (J.-W.P., S.-H.K., S.-H.B., J.H.S., N.J., B.-J.K.).ORCID 0000-0002-3656-1833
Joo Hye SungDepartment of Neurology, Korea University Medicine, Seoul (J.-W.P., S.-H.K., S.-H.B., J.H.S., N.J., B.-J.K.).
Namjoon JeonDepartment of Neurology, Korea University Medicine, Seoul (J.-W.P., S.-H.K., S.-H.B., J.H.S., N.J., B.-J.K.).
Alfredo GamboaDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.-W.P., L.E.O., A.G., C.A.S., A.D., I.B.).ORCID 0000-0002-8676-687X
Cyndya A ShibaoDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.-W.P., L.E.O., A.G., C.A.S., A.D., I.B.).ORCID 0000-0002-4518-6801
André DiedrichDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.-W.P., L.E.O., A.G., C.A.S., A.D., I.B.).
Byung-Jo KimDepartment of Neurology, Korea University Medicine, Seoul (J.-W.P., S.-H.K., S.-H.B., J.H.S., N.J., B.-J.K.).ORCID 0000-0002-0445-7185
Italo BiaggioniDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.-W.P., L.E.O., A.G., C.A.S., A.D., I.B.).ORCID 0000-0001-7667-7083
Jisc · GBVanderbilt University Medical Center · USBristol-Myers Squibb (South Korea) · KRVanderbilt University · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Hemodynamic Effects of Positive Airway Pressure to Treat Supine Hypertension and Improve Neurogenic Orthostatic HypotensionR01HL161095 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Italo Biaggioni, Luis Enrique Okamoto · 2022 to 2026
$3.2M
Automated Abdominal Binder for Orthostatic HypotensionR01HL144568 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OKAMOTO, LUIS ENRIQUE · 2020 to 2024
$2.7M
Autonomic Determinants of Postural Tachycardia SyndromeR01HL142583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL142583NHLBI NIH HHS R01 HL144568NHLBI NIH HHS R01 HL161095NIDDK NIH HHS P30 DK079307
6 · The paper itself

Abstract

backgroundStandard autonomic testing includes a 10-minute head-up tilt table test to detect orthostatic hypotension. Although this test can detect delayed orthostatic hypotension (dOH) between 3 and 10 minutes of standing, it cannot detect late-onset dOH after 10 minutes of standing.

methodsTo determine whether Valsalva maneuver responses can identify patients who would require prolonged head-up tilt table test to diagnose late-onset dOH; patients with immediate orthostatic hypotension (onset <3 minutes; n=176), early-onset dOH (onset between 3 and 10 minutes; n=68), and late-onset dOH (onset >10 minutes; n=32) were retrospectively compared with controls (n=114) with normal head-up tilt table test and composite autonomic scoring scale score of 0.

resultsChanges in baseline systolic blood pressure at late phase 2 (∆SBP

conclusionsLong PRT and short ∆HR

Indexed as

Hypotension, OrthostaticBlood PressureHeart RateHumansPostureRetrospective StudiesTilt-Table TestValsalva Maneuverautonomic nervous system diseasesclinical decision rulesdiagnostic techniques and procedureshypotension, orthostaticorthostatic intoleranceValsalva maneuver

Identifiers

PMID36695176
PMCPMC10023507
OpenAlexW4317934501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.