ArticleProceedings. Biological sciences2023
The evolution of age-specific resistance to infectious disease.
Article in Proceedings. Biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Intestinal Parasite Community Dynamics in the Critically Endangered Chinese Alligator (Ecology and evolution · 2026Article
- Coevolution of host resistance and pathogen exploitation in a propagule-mediated infection model.PLoS computational biology · 2026Article
- Pathogens pull hardest in the coevolutionary arms-race to determine age-specific transmission biases.bioRxiv : the preprint server for biology · 2025Article
- Disease resistance is more costly at younger ages: An explanation for the maintenance of juvenile susceptibility in a wild plant.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptional and hormonal profiling uncovers the interactions between plant developmental stages and RNA virus infection.The Journal of general virology · 2024Article
- Coevolution of Age-Structured Tolerance and Virulence.Bulletin of mathematical biology · 2024Article
- Article
- The Evolution of the Age of Onset of Resistance to Infectious Disease.Bulletin of mathematical biology · 2023Article
- The evolution of age-specific resistance to infectious disease.Proceedings. Biological sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Innate, infection-preventing resistance often varies between host life stages. Juveniles are more resistant than adults in some species, whereas the opposite pattern is true in others. This variation cannot always be explained by prior exposure or physiological constraints and so it has been hypothesized that trade-offs with other life-history traits may be involved. However, little is known about how trade-offs between various life-history traits and resistance at different life stages affect the evolution of age-specific resistance. Here, we use a mathematical model to explore how trade-offs with natural mortality, reproduction and maturation combine to affect the evolution of resistance at different life stages. Our results show that certain combinations of trade-offs have substantial effects on whether adults or juveniles are more resistant, with trade-offs between juvenile resistance and adult reproduction inherently more costly than trade-offs involving maturation or mortality (all else being equal), resulting in consistent evolution of lower resistance at the juvenile stage even when infection causes a lifelong fecundity reduction. Our model demonstrates how the differences between patterns of age-structured resistance seen in nature may be explained by variation in the trade-offs involved and our results suggest conditions under which trade-offs tend to select for lower resistance in juveniles than adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.