Evidence map›Paper›PMID 36694905›Full record

ArticleActa naturae

Multiple Sclerosis Is Associated with Immunoglobulin Germline Gene Variation of Transitional B Cells.

Y A Lomakin, L A Ovchinnikova, M N Zakharova, M V Ivanova, T O Simaniv, M R Kabilov, N A Bykova, V S Mukhina, A N Kaminskaya, A E Tupikin and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. CD38 connects the heart and brain.Translational psychiatry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Y A LomakinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997 Russia.
L A OvchinnikovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997 Russia.
M N ZakharovaResearch Center of Neurology, Moscow, 125367 Russia.
M V IvanovaResearch Center of Neurology, Moscow, 125367 Russia.
T O SimanivResearch Center of Neurology, Moscow, 125367 Russia.
M R KabilovInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, 630090 Russia.
N A BykovaVavilov Institute of General Genetics RAS, Moscow, 119991 Russia.
V S MukhinaVavilov Institute of General Genetics RAS, Moscow, 119991 Russia.
A N KaminskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997 Russia.
A E TupikinInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, 630090 Russia.
M Y ZakharovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997 Russia.
A V FavorovVavilov Institute of General Genetics RAS, Moscow, 119991 Russia.
S N IllarioshkinResearch Center of Neurology, Moscow, 125367 Russia.
A A BelogurovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997 Russia.
A G GabibovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997 Russia.
Research Center of Neurology · RUInstitute of Bioorganic Chemistry · RUInstitute of Bioorganic Chemistry · BYVavilov Institute of General Genetics · RUInstitute of Chemical Biology and Fundamental Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulatory functions of the B-cell compartment play an important role in the development and suppression of the immune response. Disruption of their anti-inflammatory functions may lead to the acceleration of immunopathological processes, and to autoimmune diseases, in particular. Unfortunately, the exact mechanism underlying the functioning and development of regulatory B cells (Breg) has not yet been fully elucidated. Almost nothing is known about their specificity and the structure of their B-cell receptors (BCRs). In this research, we analyzed the BCR repertoire of the transitional Breg (tBreg) subpopulation with the CD19

Indexed as

BCR-Seqgermlineimmunoglobulinmultiple sclerosisneurodegenerationNGSregulatory B cellstransitional B cellsTrB

Identifiers

PMID36694905
PMCPMC9844083
OpenAlexW4317603392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.