Evidence map›Paper›PMID 36694711›Full record

ReviewEnvironmental epigenetics2023

DNA methylation signatures as biomarkers of socioeconomic position.

Meghna Rajaprakash, Lorraine T Dean, Meredith Palmore, Sara B Johnson, Joan Kaufman, Daniele M Fallin, Christine Ladd-Acosta

Open access · goldAbstract readReview
In one paragraph

Review in Environmental epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meghna RajaprakashDepartment of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-6217-0502
Lorraine T DeanDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-2272-2755
Meredith PalmoreDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sara B JohnsonDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Joan KaufmanDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Daniele M FallinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Christine Ladd-AcostaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Johns Hopkins University · USKennedy Krieger Institute · US

Funding

Social adversities, epigenetics, and the obesity epidemicR01MD011746 · NIMHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE · 2017 to 2021
$4.4M
The role of epigenetics in the adverse effects of social environmental stressors on COPD outcomesR01MD015407 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI LADD-ACOSTA, CHRISTINE · 2021 to 2025
$2.7M
NIMHD NIH HHS R01 MD011746NIMHD NIH HHS R01 MD015407
6 · The paper itself

Abstract

This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.

Indexed as

biomarkerDNA methylationEWASsocial epigenomicssocioeconomic position

Identifiers

PMID36694711
PMCPMC9869656
OpenAlexW4311486158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.