Evidence map›Paper›PMID 36694432›Full record

ArticleBritish journal of pharmacology2024

Stimulation of platelet P2Y

Kate L Arkless, Dingxin Pan, Manu Shankar-Hari, Richard T Amison, Clive P Page, Khondaker Miraz Rahman, Simon C Pitchford

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Platelet-specific P2YRespiratory research · 2026
    Article
  2. Review
  3. Stimulation of platelet P2YBritish journal of pharmacology · 2024
    Article
  4. Exploring bias in platelet P2YBritish journal of pharmacology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kate L ArklessSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.
Dingxin PanSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.
Manu Shankar-HariSchool of Immunology and Microbial Sciences, King's College London, London, UK.ORCID 0000-0002-5338-2538
Richard T AmisonSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.ORCID 0000-0002-6616-4599
Clive P PageSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.ORCID 0000-0002-9358-3799
Khondaker Miraz RahmanChemical Biology Group, Institute of Pharmaceutical Science, King's College London, London, UK.ORCID 0000-0001-8566-8648
Simon C PitchfordSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.ORCID 0000-0003-3961-0407
King's College London · GB

Funding

Medical Research Council MR/T015845/1
6 · The paper itself

Abstract

background and purposePlatelet function during inflammation is dependent on activation by endogenous nucleotides. Non-canonical signalling via the P2Y EXPERIMENTAL APPROACH: Platelets obtained from healthy human volunteers were incubated with ADP, Ap3A, NAD KEY

resultsPlatelet aggregation and binding to fibrinogen induced by ADP was not mimicked by NAD CONCLUSION AND IMPLICATIONS: Platelet function (aggregation vs motility) can be differentially modulated by biased-agonist activation of P2Y LINKED ARTICLES: This article is part of a themed issue on Platelet purinergic receptor and non-thrombotic disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.4/issuetoc.

Indexed as

Blood PlateletsNADAdenosine DiphosphateAdenosine Diphosphate RiboseFibrinogenHumansInflammationMolecular Docking SimulationPlatelet AggregationReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12Adenosine DiphosphateAdenosine Diphosphate RiboseFibrinogenNADReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12aggregationbiased-agonistchemotaxisP2Y1platelets

Identifiers

PMID36694432
PMCPMC10952403
OpenAlexW4318027103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.