Evidence map›Paper›PMID 36694362›Full record

ArticleAdvanced healthcare materials2023

Glioblastoma Spheroid Invasion through Soft, Brain-Like Matrices Depends on Hyaluronic Acid-CD44 Interactions.

Gevick Safarians, Alireza Sohrabi, Itay Solomon, Weikun Xiao, Soniya Bastola, Bushra W Rajput, Mary Epperson, Isabella Rosenzweig, Kelly Tamura, Breahna Singer and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

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  7. GlioblastomaACS biomaterials science & engineering · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Gevick SafariansDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0001-6725-7896
Alireza SohrabiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Itay SolomonDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Weikun XiaoDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Soniya BastolaDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Bushra W RajputDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Mary EppersonDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Isabella RosenzweigDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Kelly TamuraDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Breahna SingerDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Joyce HuangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Mollie J HarrisonDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Talia SanazzaroDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Michael C CondroSemel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Harley I KornblumSemel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Stephanie K SeidlitsDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0003-3881-7166
University of California, Los Angeles · USThe University of Texas at Austin · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
Radiation-induced vascular reprogramming in glioblastomaR01NS121617 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARLEY IAN KORNBLUM · 2022 to 2026
$2.3M
Tissue-Engineered Models of Microvessel-Mediated Glioblastoma InvasionR01CA241927 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI SEIDLITS, STEPHANIE KRISTIN · 2020 to 2024
$1.9M
Engineered microenvironments as biomimetic culture platforms for studying the role of brain extracellular matrix in acquisition of resistance to EGFR inhibition across multiple biological scalesR21NS093199 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NATHANSON, DAVID A., SEIDLITS, STEPHANIE KRISTIN · 2015 to 2016
$424k
NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA241927NINDS NIH HHS R01 NS121617NINDS NIH HHS R21 NS093199
6 · The paper itself

Abstract

Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) patients. GBM cells aggressively invade the brain parenchyma while encountering spatiotemporal changes in their local ECM, including HA concentration. To investigate how varying HA concentrations affect GBM invasion, patient-derived GBM cells are cultured within a soft, 3D matrix in which HA concentration is precisely varied and cell migration observed. Data demonstrate that HA concentration can determine the invasive activity of patient-derived GBM cells in a biphasic and highly sensitive manner, where the absolute concentration of HA at which cell migration peaked is specific to each patient-derived line. Furthermore, evidence that this response relies on phosphorylated ezrin, which interacts with the intracellular domain of HA-engaged CD44 to effectively link the actin cytoskeleton to the local ECM is provided. Overall, this study highlights CD44-HA binding as a major mediator of GBM cell migration that acts independently of integrins and focal adhesion complexes and suggests that targeting HA-CD44-ezrin interactions represents a promising therapeutic strategy to prevent tumor cell invasion in the brain.

Indexed as

GlioblastomaBrainCell Line, TumorCell MovementHumansHyaluronan ReceptorsHyaluronic AcidCD44 protein, humanHyaluronan ReceptorsHyaluronic AcidCD44ezringlioblastomahyaluronic acidshydrogels

Identifiers

PMID36694362
PMCPMC10238626
OpenAlexW4318025404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.