Evidence map›Paper›PMID 36694274›Full record

ArticleVirulence2023

The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses.

Aditi Sharma, Sajan Chandrangadhan Achi, Stella-Rita Ibeawuchi, Mahitha Shree Anandachar, Hobie Gementera, Uddeep Chaudhury, Fatima Usmani, Kevin Vega, Ibrahim M Sayed, Soumita Das

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Exploring the Effects ofAnimals : an open access journal from MDPI · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Aditi SharmaDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Sajan Chandrangadhan AchiDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Stella-Rita IbeawuchiDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Mahitha Shree AnandacharDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Hobie GementeraDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Uddeep ChaudhuryDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Fatima UsmaniDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Kevin VegaDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Ibrahim M SayedDepartment of Pathology, University of California San Diego; San Diego, California, USA.
Soumita DasDepartment of Pathology, University of California San Diego; San Diego, California, USA.
University of San Diego · USUniversity of California, San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Macrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9M
Innate responses following infection with enteric microbesR01DK107585 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2016 to 2020
$2.2M
The host-microbe-metformin interplay in the aged gutR56AG069689 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2020 to 2020
$394k
NCATS NIH HHS UL1 TR001442NIAID NIH HHS R01 AI155696NIA NIH HHS R56 AG069689NIDDK NIH HHS R01 DK107585
6 · The paper itself

Abstract

Microbial sensors play an essential role in maintaining cellular homoeostasis. Our knowledge is limited on how microbial sensing helps in differential immune response and its link to inflammatory diseases. Recently we have confirmed that ELMO1 (Engulfment and Cell Motility Protein-1) present in cytosol is involved in pathogen sensing, engulfment, and intestinal inflammation. Here, we show that ELMO1 interacts with another sensor, NOD2 (Nucleotide-binding oligomerization domain-containing protein 2), that recognizes bacterial cell wall component muramyl dipeptide (MDP). The polymorphism of NOD2 is linked to Crohn's disease (CD) pathogenesis. Interestingly, we found that overexpression of ELMO1 and mutant NOD2 (L1007fs) were not able to clear the CD-associated adherent invasive

Indexed as

Crohn DiseaseEscherichia coliAdaptor Proteins, Signal TransducingAnimalsImmunityIntestinesMacrophagesMiceNod2 Signaling Adaptor ProteinAdaptor Proteins, Signal TransducingELMO1 protein, mouseNod2 protein, mouseNod2 Signaling Adaptor Protein3D-organoidAIEC-LF82, epithelial cells and macrophagesbacterial engulfmentELMO-1Microbial sensorsNOD2

Identifiers

PMID36694274
PMCPMC9980453
OpenAlexW4317888636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.