ReviewReviews in endocrine & metabolic disorders2023
Phase angle in assessment and monitoring treatment of individuals with respiratory disease.
Review in Reviews in endocrine & metabolic disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Prognostic Value of Multifrequency Bioelectrical Impedance Analysis in Chronic Obstructive Pulmonary Disease: Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Bioelectrical impedance analysis-derived phase angle (PhA) in lung cancer patients: a systematic review.BMC cancer · 2024Pooled it
- Association of phase angle with malnutrition and sarcopenia in interstitial lung disease: a cross-sectional analysis of body composition and functional decline.BMC pulmonary medicine · 2026Observational
- Differential predictive value of phase angle for malnutrition and physical impairment in respiratory patients: the moderating role of sarcopenia.Frontiers in nutrition · 2026Article
- Bioelectrical impedance-derived phase angle as a contextual indicator for steatotic liver disease and hepatic fat estimation.Frontiers in nutrition · 2026Article
- Phase angle as an early-warning indicator of glycaemic control in adults with type 1 diabetes mellitus: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Analysis of body composition characteristics in patients with type 1 diabetes mellitus: a case-control study based on a bioelectrical impedance analyzer.Frontiers in medicine · 2026Article
- Cachexia Phenotyping Through Morphofunctional Assessment and Mitocondrial Biomarkers (GDF-15 and PGC-1α) in Idiopathic Pulmonary Fibrosis.Nutrients · 2025Observational
- Association between phase angle and all-cause mortality in adults aged 18-49 years: NHANES 1999-2004.Scientific reports · 2025Article
- Phase angle associates with severity and mortality in acute-on-chronic liver failure.Frontiers in medicine · 2025Article
- Article
- Lower bioelectrical impedance phase angle is associated with COPD and is a marker for increased risks in elderly COPD patients.Frontiers in medicine · 2025Article
- Phase angle as a predictor of prolonged length of hospital stay and adverse outcomes in elderly medical inpatients: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Phase angle is a useful predicting indicator for protein-energy wasting and cardiovascular risk among maintenance hemodialysis patients.Scientific reports · 2024Observational
- Article
- Association between Physical Activity and Phase Angle Obtained via Bioelectrical Impedance Analysis in South Korean Adults Stratified by Sex.Nutrients · 2024Article
- Article
- Rectus Femoris Cross-Sectional Area and Phase Angle asPredictors of 12-Month Mortality in Idiopathic Pulmonary Fibrosis Patients.Nutrients · 2023Article
- Phase angle in applications of bioimpedance in health and disease.Reviews in endocrine & metabolic disorders · 2023Review
- Future lines of research on phase angle: Strengths and limitations.Reviews in endocrine & metabolic disorders · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phase angle (PhA) represents a raw variable measured with bioelectrical impedance analysis (BIA) that is used to assess malnutrition in many diseases, including respiratory diseases, mainly chronic obstructive pulmonary disease (COPD). COPD patients with reduced PhA are older, more hypoxic and hypercapnic; patients with more severe COPD have reduced cell mass, evident skeletal muscle depletion, and worsening gas exchange. Malnourished patients with stable COPD in long-term oxygen therapy (LTOT) have more intense dyspnea at rest, greater weight loss over the past 12 months, and more exacerbations per year. Multiple regression analysis highlighted the significance of PhA° in the estimation of muscle strength: hand grip strength (HGS) and in that of respiratory muscles: maximal inspiratory pressure / max. expiratory pressure ratio (MIP/MEP). Furthermore, the relationship between PhA° and all-cause mortality in COPD patients was confirmed with the Cox regression model, Kaplan-Meier test, and log-rank tests. The role of malnutrition in idiopathic pulmonary fibrosis (IPF) is confirmed by the PhA° measurements which, regardless of body weight, is associated with the reduction in muscle mass of these patients, reduces their strength and exercise capacity, and greatly influences the prognosis. In conclusion PhA is a novel biomarker of morbidity and mortality in patients with severe respiratory diseases.
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