Evidence map›Paper›PMID 36694027›Full record

ArticlePediatric research2023

Cerebroprotective actions of hydrogen sulfide in the epileptic brain in newborn pigs.

Jianxiong Liu, Massroor Pourcyrous, Alexander L Fedinec, Helena Parfenova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jianxiong LiuDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.
Massroor PourcyrousDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.
Alexander L FedinecDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.
Helena ParfenovaDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA. hparfeno@uthsc.edu.
University of Tennessee Health Science Center · US

Funding

Endothelial Vasoprotection by HypothermiaR01NS105655 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PARFENOVA, HELENA · 2018 to 2022
$2.1M
Neonatal cerebral vascular injury by prolonged asphyxiaR01NS134659 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Helena Parfenova · 2024 to 2026
$1.5M
Astrocyte functions in neonatal brainR01NS101717 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PARFENOVA, HELENA · 2017 to 2020
$1.3M
NINDS NIH HHS R01 NS101717NINDS NIH HHS R01 NS105655NINDS NIH HHS R01 NS134659
6 · The paper itself

Abstract

backgroundNeonatal epileptic seizures cause postictal dysregulation of cerebral blood flow. Hydrogen sulfide (H

methodsEpileptic seizures were induced in newborn pigs using bicuculline. The effects of the CBS inhibitor aminooxyacetate (AOA) and the H

resultsBrain H

conclusionsH IMPACT: Epileptic seizures in neonates lead to prolonged postictal cerebral vascular dysregulation. The role of hydrogen sulfide (H

Indexed as

EpilepsyHydrogen SulfideHyperemiaAnimalsAnimals, NewbornAntioxidantsBrainEndothelial CellsSeizuresSulfidesSwineVasodilator AgentsAntioxidantsHydrogen Sulfidesodium bisulfideSulfidesVasodilator Agents

Identifiers

PMID36694027
PMCPMC10363572
OpenAlexW4317898734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.