Molecular dynamics study of Cl

Zhi Wei Zeng, Paul Linsdell, Régis Pomès

Open access · hybridAbstract read

In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

4.9field-weighted citation impact, top 4% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches.Pharmaceuticals (Basel, Switzerland) · 2024
Review
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation.Cellular and molecular life sciences : CMLS · 2024
Article
Structural identification of a selectivity filter in CFTR.Proceedings of the National Academy of Sciences of the United States of America · 2024
Article
Computational analysis of long-range allosteric communications in CFTR.eLife · 2023
Article
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.The Journal of membrane biology · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhi Wei ZengMolecular Medicine, Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.ORCID http://orcid.org/0000-0002-2631-8311

Paul LinsdellDepartment of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, NS, B3H 1X5, Canada.

Régis PomèsMolecular Medicine, Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. pomes@sickkids.ca.ORCID http://orcid.org/0000-0003-3068-9833

University of Toronto · CADalhousie University · CA

Funding

CIHR MOP130461hospital for sick children Restracomp

6 · The paper itself

Abstract

The recent elucidation of atomistic structures of Cl

Indexed as

ChloridesCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorHumansIon TransportMolecular Dynamics SimulationCFTR protein, humanChloridesCystic Fibrosis Transmembrane Conductance RegulatorATP-binding cassetteIon solvationMembrane proteinMolecular mechanismPore hydrationProtein dynamics

Identifiers

PMID36694009

DOI10.1186/1758-2946-5-39

PMCPMC9873711

OpenAlexW4317864565

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.