Evidence map›Paper›PMID 36693922›Full record

ArticleCellular & molecular immunology2023

FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes.

Wenjuan Yang, Rukun He, Hao Qu, Wenwen Lian, Yue Xue, Tao Wang, Wenlong Lin, Peishuo Zhu, Meng Xia, Lihua Lai and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  9. TRIM21enhances IL-17A signaling and drives autoimmune myocarditis by promoting TRAF3 lysosomaldegradation in cardiac fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. N4BP1 acts as a potent negative regulator of IL-17 signaling by blocking the translation of Act1 mRNA.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  11. Article
  12. Article
  13. A review of core immuno-inflammatory mechanisms and key regulatory targets in psoriasis.American journal of clinical and experimental immunology · 2026
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Wenjuan Yang *Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Rukun He *Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Hao Qu *Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
Wenwen LianInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Yue XueInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Tao WangInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Wenlong LinInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Peishuo ZhuInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
Meng XiaInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China. xiameng.dream@zju.edu.cn.
Lihua LaiDepartment of Pharmacology, Zhejiang University School of Medicine, 310058, Hangzhou, China. lailihua@zju.edu.cn.ORCID http://orcid.org/0000-0003-1459-018X
Qingqing WangInstitute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China. wqq@zju.edu.cn.ORCID http://orcid.org/0000-0002-0415-0052
Zhejiang University · CNSecond Affiliated Hospital of Zhejiang University · CNZhejiang Lab · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a common chronic inflammatory skin disease characterized by inflammatory cell infiltration and epidermal hyperplasia. However, the regulatory complexity of cytokine and cellular networks still needs to be investigated. Here, we show that the expression of FXYD3, a member of the FXYD domain-containing regulators of Na

Indexed as

Membrane ProteinsNeoplasm ProteinsPsoriasisTNF Receptor-Associated Factor 3AnimalsCytokinesDisease Models, AnimalHumansImiquimodInterleukin-17KeratinocytesMiceSkinCytokinesFXYD3 protein, humanImiquimodInterleukin-17Membrane ProteinsNeoplasm ProteinsTNF Receptor-Associated Factor 3TRAF3 protein, humanFXYD3IL-17 signalingKeratinocytesPsoriasisTRAF3

Identifiers

PMID36693922
PMCPMC9971024
OpenAlexW4317874806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.