Evidence map›Paper›PMID 36693842›Full record

ArticleNature communications2023

In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy.

Wenquan Ou, Samantha Stewart, Alisa White, Elyahb A Kwizera, Jiangsheng Xu, Yuanzhang Fang, James G Shamul, Changqing Xie, Suliat Nurudeen, Nikki P Tirada and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 70 citations in OpenAlex.

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  14. Tissue Ablation: Applications and Perspectives.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Wenquan OuFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Samantha StewartFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Alisa WhiteFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Elyahb A KwizeraFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Jiangsheng XuFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Yuanzhang FangDepartment of Medical and Molecular Genetics and Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
James G ShamulFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Changqing XieThoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-5271-0050
Suliat NurudeenMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA.
Nikki P TiradaMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA.
Xiongbin LuDepartment of Medical and Molecular Genetics and Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-7987-9825
Katherine H R TkaczukMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, 21201, USA.ORCID 0000-0002-5978-5215
Xiaoming HeFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA. shawnhe@umd.edu.ORCID 0000-0003-0125-6086
University of Maryland, College Park · USUniversity of Maryland, Baltimore · USIndiana University Health · USNational Institutes of Health · US

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9M
Cancer Stem Cells in CholangiocarcinomaZIABC011888 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI XIE, CHANGQING · 2019 to 2024
$3.4M
Nanotechnology for targeted therapy and fundamental understanding oftherapeutic resistance in triple negative breast cancerR01CA243023 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HE, XIAOMING · 2020 to 2024
$2.0M
NCI NIH HHS R01 CA243023NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

Cancer immunotherapy that deploys the host's immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). Here, we report an in-situ cryo-immune engineering (ICIE) strategy for turning the TME from immunologically "cold" into "hot". In particular, after the ICIE treatment, the ratio of the CD8

Indexed as

Antineoplastic AgentsCryotherapyImmunotherapyNeoplasmsTumor MicroenvironmentAnimalsCell Line, TumorFemaleMiceNanotechnologyAntineoplastic Agents

Identifiers

PMID36693842
PMCPMC9873931
OpenAlexW4317894265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.