Evidence map›Paper›PMID 36693838›Full record

ArticleCell death & disease2023

Caspase-9 driven murine model of selective cell apoptosis and efferocytosis.

Lena Batoon, Amy J Koh, Rahasudha Kannan, Laurie K McCauley, Hernan Roca

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Engineering Efferocytosis for Bone Regeneration.Macromolecular bioscience · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Efferocytosis and Bone Dynamics.Current osteoporosis reports · 2024
    Review
  14. Article
  15. Review
  16. Review
  17. Programmed Cell Death in Liver Fibrosis.Journal of inflammation research · 2023
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lena BatoonDepartment of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0002-1831-4601
Amy J KohDepartment of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, USA.
Rahasudha KannanDepartment of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0002-6770-7559
Laurie K McCauleyDepartment of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, USA. mccauley@umich.edu.ORCID 0000-0001-9173-9123
Hernan RocaDepartment of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, USA. rocach@umich.edu.ORCID 0000-0003-2896-1455
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Tumor microvesicle-mediated modulation of the bone microenvironmentP01CA093900 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KELLER, EVAN T · 2004 to 2024
$29.6M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
ANABOLIC MECHANISMS OF PTH ACTION IN BONER01DK053904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 1998 to 2016
$4.6M
PTH and Calcium Synergy for Craniofacial RegenerationR01DE022327 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 2012 to 2022
$3.8M
The role of efferocytic macrophages in bone formationR56AR077539 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K., ROCA, HERNAN · 2021 to 2021
$446k
Anabolic Mechanisms of PTH Action in BoneR56DK053904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 2018 to 2018
$156k
NCI NIH HHS P01 CA093900NCI NIH HHS P30 CA046592NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R56 AR077539NIDCR NIH HHS R01 DE022327NIDDK NIH HHS R01 DK053904NIDDK NIH HHS R56 DK053904
6 · The paper itself

Abstract

Apoptosis and efficient efferocytosis are integral to growth, development, and homeostasis. The heterogeneity of these mechanisms in different cells across distinct tissues renders it difficult to develop broadly applicable in vivo technologies. Here, we introduced a novel inducible caspase-9 (iCasp9) mouse model which allowed targeted cell apoptosis and further facilitated investigation of concomitant efferocytosis. We generated iCasp9

Indexed as

ApoptosisCaspase 9PhagocytosisAnimalsCaspase 3Disease Models, AnimalMiceCaspase 3Caspase 9

Identifiers

PMID36693838
PMCPMC9873735
OpenAlexW4317831273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.