Evidence map›Paper›PMID 36693822›Full record

ArticleTranslational psychiatry2023

Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury.

Murray B Stein, Sonia Jain, Livia Parodi, Karmel W Choi, Adam X Maihofer, Lindsay D Nelson, Pratik Mukherjee, Xiaoying Sun, Feng He, David O Okonkwo and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 1 country.

Murray B SteinDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA. mstein@health.ucsd.edu.ORCID 0000-0001-9564-2871
Sonia JainBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Livia ParodiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Karmel W ChoiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Adam X MaihoferDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Lindsay D NelsonDepartments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Pratik MukherjeeDepartment of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, USA.
Xiaoying SunBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Feng HeBiostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Joseph T GiacinoDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.
Frederick K KorleyDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.
Mary J VassarBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA.
Claudia S RobertsonDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Michael A McCreaDepartments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Nancy TemkinDepartments of Neurological Surgery and Biostatistics, University of Washington, Seattle, WA, USA.
Amy J MarkowitzBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-6051-3594
Jonathan RosandCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Geoffrey T ManleyBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA.
TRACK-TBI Investigators
San Francisco General Hospital · USUniversity of California San Diego · USBroad Institute · USBaylor College of Medicine · USHarvard University · USMedical College of Wisconsin · USVirginia Commonwealth University · USMassachusetts General Hospital · USUC San Diego Health System · USUniversity of Maryland, College Park · USUniversity of Michigan · USUniversity of Pennsylvania · USUniversity of Pittsburgh Medical Center · USUniversity of Utah · USUniversity of Washington · US

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
Integrating Health Records, Genomic, and Social Data to Stratify Adolescent Depression RiskK08MH127413 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, KARMEL · 2021 to 2025
$987k
NIMH NIH HHS K08 MH127413NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

Many patients with mild traumatic brain injury (mTBI) are at risk for mental health problems such as posttraumatic stress disorder (PTSD). The objective of this study was to determine whether the polygenic risk for PTSD (or for related mental health disorders or traits including major depressive disorder [MDD] and neuroticism [NEU]) was associated with an increased likelihood of PTSD in the aftermath of mTBI. We used data from individuals of European ancestry with mTBI enrolled in TRACK-TBI (n = 714), a prospective longitudinal study of level 1 trauma center patients. One hundred and sixteen mTBI patients (16.3%) had probable PTSD (PCL-5 score ≥33) at 6 months post-injury. We used summary statistics from recent GWAS studies of PTSD, MDD, and NEU to generate polygenic risk scores (PRS) for individuals in our sample. A multivariable model that included age, sex, pre-injury history of mental disorder, and cause of injury explained 7% of the variance in the PTSD outcome; the addition of the PTSD-PRS (and five ancestral principal components) significantly increased the variance explained to 11%. The adjusted odds of PTSD in the uppermost PTSD-PRS quintile was nearly four times higher (aOR = 3.71, 95% CI 1.80-7.65) than in the lowest PTSD-PRS quintile. There was no evidence of a statistically significant interaction between PTSD-PRS and prior history of mental disorder, indicating that PTSD-PRS had similar predictive utility among those with and without pre-injury psychiatric illness. When added to the model, neither MDD-PRS nor NEU-PRS were significantly associated with the PTSD outcome. These findings show that the risk for PTSD in the context of mTBI is, in part, genetically influenced. They also raise the possibility that an individual's PRS could be clinically actionable if used-possibly with other non-genetic predictors-to signal the need for enhanced follow-up and early intervention; this precision medicine approach needs to be prospectively studied.

Indexed as

Brain ConcussionMajor Depressive DisorderStress Disorders, Post-TraumaticHumansLongitudinal StudiesProspective Studies

Identifiers

PMID36693822
PMCPMC9873804
OpenAlexW4317876237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.