Evidence map›Paper›PMID 36693375›Full record

ArticleCell2023

Picking a (neuroimmune) fight against fragile regulation of addiction.

Min Woo Kim, Jonathan Kipnis

Open access · greenAbstract readComment
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Min Woo KimCenter for Brain Immunology and Glia (BIG), Medical Scientist Training Program, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA.
Jonathan KipnisCenter for Brain Immunology and Glia (BIG), Medical Scientist Training Program, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: kipnis@wustl.edu.
Washington University in St. Louis · US

Funding

Immune system supports brain functionR37AG034113 · NIA · WASHINGTON UNIVERSITY · PI Jonathan Kipnis · 2020 to 2026
$3.7M
NIA NIH HHS R37 AG034113
6 · The paper itself

Abstract

T cells and their derived cytokines have been shown to modulate brain function. In this issue of Cell, Zhu, Yan, and colleagues demonstrate that opioid use impacts the crosstalk between the CNS and the peripheral immune system. Regulatory T cell (Treg)-derived IFN-γ signaling translates into synaptic weakening in the nucleus accumbens (NAc) to impart withdrawal-induced behavioral dysfunction.

Indexed as

Nucleus AccumbensOpioid-Related DisordersSignal TransductionCytokinesCytokines

Identifiers

PMID36693375
PMCPMC10205172
OpenAlexW4318027724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.